TY - JOUR T1 - α-Emitters for Radiotherapy: From Basic Radiochemistry to Clinical Studies—Part 1 JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 878 LP - 884 DO - 10.2967/jnumed.116.186338 VL - 59 IS - 6 AU - Sophie Poty AU - Lynn C. Francesconi AU - Michael R. McDevitt AU - Michael J. Morris AU - Jason S. Lewis Y1 - 2018/06/01 UR - http://jnm.snmjournals.org/content/59/6/878.abstract N2 - With a short particle range and high linear energy transfer, α-emitting radionuclides demonstrate high cell-killing efficiencies. Even with the existence of numerous radionuclides that decay by α-particle emission, only a few of these can reasonably be exploited for therapeutic purposes. Factors including radioisotope availability and physical characteristics (e.g., half-life) can limit their widespread dissemination. The first part of this review will explore the diversity, basic radiochemistry, restrictions, and hurdles of α-emitters. ER -