PT  - JOURNAL ARTICLE
AU  - Poty, Sophie
AU  - Francesconi, Lynn C.
AU  - McDevitt, Michael R.
AU  - Morris, Michael J.
AU  - Lewis, Jason S.
TI  - α-Emitters for Radiotherapy: From Basic Radiochemistry to Clinical Studies—Part 1
AID  - 10.2967/jnumed.116.186338
DP  - 2018 Jun 01
TA  - Journal of Nuclear Medicine
PG  - 878--884
VI  - 59
IP  - 6
4099  - http://jnm.snmjournals.org/content/59/6/878.short
4100  - http://jnm.snmjournals.org/content/59/6/878.full
SO  - J Nucl Med2018 Jun 01; 59
AB  - With a short particle range and high linear energy transfer, α-emitting radionuclides demonstrate high cell-killing efficiencies. Even with the existence of numerous radionuclides that decay by α-particle emission, only a few of these can reasonably be exploited for therapeutic purposes. Factors including radioisotope availability and physical characteristics (e.g., half-life) can limit their widespread dissemination. The first part of this review will explore the diversity, basic radiochemistry, restrictions, and hurdles of α-emitters.