TY - JOUR T1 - <strong>Evaluation of Cardiac Sympathetic Denervation using 18F-FDOPA PET-CT in Idiopathic Parkinson Disease</strong> JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 230 LP - 230 VL - 59 IS - supplement 1 AU - Harish Goyal AU - Chetan Patel AU - Girish Parida AU - VINAY GOYAL AU - Chandrasekhar Bal Y1 - 2018/05/01 UR - http://jnm.snmjournals.org/content/59/supplement_1/230.abstract N2 - 230Objectives: To evaluate the myocardial sympathetic denervation by using L-3,4-dihydroxy-6-F-18fluorodihydroxyphenylalanine (18F-FDOPA) PET-CT in patients with early and advanced Idiopathic Parkinson’s disease (IPD). Materials and methods This prospective study was approved by the institutional review board and informed consent was obtained from all subjects. We evaluated a total of 49 18F-FDOPA PET-CT cardiac images. These included 30 IPD patients- 16 early IPD (UPDRS = 30.3±5.6 and H&amp;Y less than 2.0) and 14 advanced IPD (UPDRS =54.3±7.2 and H&amp;Y=2.0-4.0). All patients had been referred for dopaminergic imaging for movement disorder after undergoing a detailed clinical examination. Nineteen age matched subjects who had undergone 18F-FDOPA PET-CT for indication other than Parkinsonism and had no history of CAD or coronary risk factors, were recruited as controls. On cardiac images, myocardium to liver SUVmax ratio (MLR) and myocardium to mediastinal vessel SUVmax ratio (MMR) were derived. For regional analysis, these ratios were calculated separately for inter-ventricular septum (IVS), apex, anterior wall, inferior wall and lateral wall of the LV. The global and regional values of MMR and MLR derived from controls were compared with those of IPD patients. Unpaired T test was used for comparison of MMR and MLR between patients with IPD and those of control group. Results The mean global MLR in controls, subjects with early IPD and advance IPD are 1.15±0.16, 0.86±0.09 and 0.69±0.14, respectively. And the mean global MMR in controls, subjects with early IPD and advance IPD are 1.84±0.23, 1.68±0.18 and 1.49±0.21, respectively. We compared the ratios between controls and patients with early IPD; in patients with early IPD and advanced IPD &amp; controls and patients with advanced IPD. The difference was found to be statistically significant (p &lt;0.05 for all). On regional analysis, there was preserved FDOPA uptake in the anterior wall and septum with no significant difference in the regional MLR &amp; MMR between the controls and the patient groups. However, there was statistically significant reduction in FDOPA uptake (regional MLR &amp; MMR) in the lateral wall, inferior wall and apex in patients with early &amp; advanced IPD (p &lt;0.05). Conclusion FDOPA PET-CT can be used in evaluation of global and regional cardiac sympathetic denervation in IPD patients. ER -