RT Journal Article
SR Electronic
T1 Evaluation of LAT1 tracer <sup>18</sup>F-FAMT in the inflammatory lesions -comparison study with <sup>18</sup>F-FDG PET
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1108
OP 1108
VO 59
IS supplement 1
A1 Sakai, Tatsuya
A1 Watabe, Tadashi
A1 Hirai, Nobuto
A1 Tani, Naoki
A1 Ikeda, Hayato
A1 Naka, Sadahiro
A1 Kanai, Yasukazu
A1 Tatsumi, Mitsuaki
A1 Shimosegawa, Eku
A1 Hatazawa, Jun
YR 2018
UL http://jnm.snmjournals.org/content/59/supplement_1/1108.abstract
AB 1108Objectives: 18F-FDG is mainly used as an oncology PET-tracer. However, 18F-FDG can show false positive findings because it also accumulates in the inflammatory lesion. L-[3-18F]-α-methyl tyrosine (18F-FAMT) is reported as a tumor specific tracer as a substrate of L-type amino acid transporter 1 (LAT1), which is expressed in major cancer cells but not in normal tissue. The purpose of this study was to evaluate 18F-FAMT as a next oncology PET tracer by comparing with 18F-FDG. [Method] Four mice with inflammation (NOD mouse, body weight = 22.3 ± 0.3 g, 8 weeks old) were investigated in this study. Mouse model of inflammation was established by subcutaneous injection of turpentine oil (0.05 ml) in the bilateral flank regions. Static PET scans were performed 50min after the intravenous injection of 18F-FDG at day 4 (20.8 ± 2.4 MBq), and 18F-FAMT at day 5 (20.1 ± 1.2 MBq) under isoflurane anesthesia. Volumes of interest were placed on the inflammatory lesion to measure SUV using Pmod software (ver 3.6). Uptakes of the lesions were compared between 18F-FAMT and 18F-FDG by paired t-test. [Result] Visual analysis showed that uptakes of 18F-FAMT in the inflammatory lesions were almost as low as the background level. To the contrary, moderate uptakes were observed on 18F-FDG PET. The SUVmax of the inflammatory lesions were 1.37 ± 0.11 in the 18F-FDG PET and 0.37 ± 0.05 in the 18F-FAMT PET. The SUVmax of 18F-FAMT was significantly lower than that of 18F-FDG (p&lt;0.01 by paired t-test). [Conclusion] 18F-FDG showed high uptakes on inflammatory lesions as previously reported. 18F-FAMT showed lower accumulation in inflammation compared to 18F-FDG and it is expected to be a tumor specific PET tracer to reduce false positive findings in the clinical oncology.