RT Journal Article SR Electronic T1 Suspicious for recurrent low and high grade glioma and indeterminate MRI: the role of 18F-DOPA PET/CT JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1691 OP 1691 VO 59 IS supplement 1 A1 Laura Evangelista A1 Marta Burei A1 Anna Rita Cervino A1 Pasquale Reccia A1 Lea Cuppari YR 2018 UL http://jnm.snmjournals.org/content/59/supplement_1/1691.abstract AB 1691Objectives: ACKGROUND. The aim of present study was to assess the role of 18F-FDOPA PET/CT in patients who had a suspicious forrecurrent low and high grade glioma but with an indeterminate MRI.MATERIALS AND METHODS . From a monocentric database, we retrospectively analyzed 21 patients (median age: 60 yrs;19-80) who underwent 18F- DOPA PET/CT for the restaging of low and high grade glioma. All PET/CT images werere-examined by two nuclear medicine physicians. Both visual and semiquantitative analysis was used for the interpretation ofimages. At visual analysis, PET/CT was defined as positive in case of a DOPA uptake in the lesion (identified by MRI) higherthan controlateral striatum uptake. For the semiquantitative analysis, the ratios between SUVmax of the lesion and SUVmax ofthe striatum (T/S)/normal brain tissue (T/B) equal to 1 and 2 respectively were used. Clinical reassessment consisted of standardevaluation including MRI and assessment of neurological symptoms. The agreement between visual and semiquantitativeanalysis was obtained by k statistical analysis. Diagnostic performance was calculated by standard methods.RESULTS. Six patients had a low grade glioma and 14 a high grade. At visual analysis, 15 (75%) patients had a positive PET/CTresult, in particular 4 with a low grade glioma and 11 with a high grade (67% and 79%, respectively). Based onsemiquantitative analysis, 14 (70%) and 14 (70%) patients had a positive PET/CT, respectively for T/S and T/B. The agreementbetween visual and semiquantitative analysis was 88% (p<0.001). In accordance with clinical reassessment available in 13patients, 10 subjects had recurrence of disease. Sensitivity, specificity, positive and negative predictive value of PET/CT basedon visual and semiquantitative analysis were 90%, 100%, 100% and 75% versus 80%, 100%, 100% and 60%, respectively.CONCLUSIONS. In patients with suspicious for recurrent low and high grade glioma, DOPA PET/CT has a high sensitivity andspecificity. Therefore, in case of indeterminate MRI, DOPA PET can anticipate the presence of recurrent disease useful for thetreatment planning.