RT Journal Article
SR Electronic
T1 Clinical assessment of the statistical images for the brain perfusion SPECT using common normal database constructed with CT based-attenuation correction and resolution compensation: a multicenter study
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1657
OP 1657
VO 59
IS supplement 1
A1 Yoshitaka Inui
A1 Takashi Ichihara
A1 Masaki Uno
A1 Kengo Ito
A1 Hidehiko Okazawa
A1 Hironori Nishibori
A1 Yasutaka Ichikawa
A1 Takahiro Yamazaki
A1 Hiroshi Toyama
YR 2018
UL http://jnm.snmjournals.org/content/59/supplement_1/1657.abstract
AB 1657Background: We have established the common normal database (NDB), which can be used in multicenter, for statistical analysis of brain perfusion SPECT with triple energy window (TEW) scatter correction (SC), CT based non-uniform attenuation correction (CTAC), and the spatial resolution compensation. Objectives: The aim of this study was to evaluate the tendency of the statistical images using the new common NDB with CTAC (CTAC-NDB) method and compare with the conventional NDB (C-NDB) with uniform attenuation correction of Chang’s method clinically. Methods: We recruited total 46 patients (22 women and 24 men, mean age, 73.6 ± 6.4 years, MMSE score, 20.4 ± 6.3) with mild cognitive impairment (MCI) or dementias such as Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), and AD with vascular dementia from three institutions. The 3-dimensional stereotactic surface projections (3D-SSP) technique was used to analyze the data obtained from the 123I-IMP brain perfusion SPECT images comparing with both CTAC-NDB and C-NBD. We assessed each 3D-SSP z-score map visually how the specific findings such as AD/DLB pattern or FTD pattern changed. In addition, we applied stereotactic extraction estimation (SEE) analysis software to measure the regional z-score and extent as semiquantitative assessment. Results: In the visual assessment, 97% of cases demonstrated clearer finding in parietotemporal association cortex, inferior temporal, frontal, and lateral occipital cortex when we used CTAC-NDB comparing with C-NDB. In contrast, the findings of the medial cerebral regions including precuneus and posterior cingulate became indistinct in 70% of cases and 30% of cases did not show any change. In the semiquantitative analysis, we also found a similar tendency in the mean z-score at three institutions. Conclusion: The common CTAC-NDB with the spatial resolution compensation would be available in multicenter clinically, because the findings of the statistical images in patients with MCI and dementias showed similar tendency.