TY - JOUR T1 - Clinical assessment of the statistical images for the brain perfusion SPECT using common normal database constructed with CT based-attenuation correction and resolution compensation: a multicenter study JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1657 LP - 1657 VL - 59 IS - supplement 1 AU - Yoshitaka Inui AU - Takashi Ichihara AU - Masaki Uno AU - Kengo Ito AU - Hidehiko Okazawa AU - Hironori Nishibori AU - Yasutaka Ichikawa AU - Takahiro Yamazaki AU - Hiroshi Toyama Y1 - 2018/05/01 UR - http://jnm.snmjournals.org/content/59/supplement_1/1657.abstract N2 - 1657Background: We have established the common normal database (NDB), which can be used in multicenter, for statistical analysis of brain perfusion SPECT with triple energy window (TEW) scatter correction (SC), CT based non-uniform attenuation correction (CTAC), and the spatial resolution compensation. Objectives: The aim of this study was to evaluate the tendency of the statistical images using the new common NDB with CTAC (CTAC-NDB) method and compare with the conventional NDB (C-NDB) with uniform attenuation correction of Chang’s method clinically. Methods: We recruited total 46 patients (22 women and 24 men, mean age, 73.6 ± 6.4 years, MMSE score, 20.4 ± 6.3) with mild cognitive impairment (MCI) or dementias such as Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), and AD with vascular dementia from three institutions. The 3-dimensional stereotactic surface projections (3D-SSP) technique was used to analyze the data obtained from the 123I-IMP brain perfusion SPECT images comparing with both CTAC-NDB and C-NBD. We assessed each 3D-SSP z-score map visually how the specific findings such as AD/DLB pattern or FTD pattern changed. In addition, we applied stereotactic extraction estimation (SEE) analysis software to measure the regional z-score and extent as semiquantitative assessment. Results: In the visual assessment, 97% of cases demonstrated clearer finding in parietotemporal association cortex, inferior temporal, frontal, and lateral occipital cortex when we used CTAC-NDB comparing with C-NDB. In contrast, the findings of the medial cerebral regions including precuneus and posterior cingulate became indistinct in 70% of cases and 30% of cases did not show any change. In the semiquantitative analysis, we also found a similar tendency in the mean z-score at three institutions. Conclusion: The common CTAC-NDB with the spatial resolution compensation would be available in multicenter clinically, because the findings of the statistical images in patients with MCI and dementias showed similar tendency. ER -