RT Journal Article
SR Electronic
T1 Ultrafast Brain Perfusion SPECT Using a CZT Semiconductor Gamma Camera
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1656
OP 1656
VO 59
IS supplement 1
A1 Iichiro Osawa
A1 Takashi Ushimi
A1 Nanami Okano
A1 Kaiji Inoue
A1 Eito Kozawa
A1 Mamoru Niitsu
A1 Ichiro Matsunari
YR 2018
UL http://jnm.snmjournals.org/content/59/supplement_1/1656.abstract
AB 1656Objectives: Prior myocardial perfusion SPECT studies have shown that ultrafast imaging is feasible using CZT-based SPECT owing to improved image quality compared with conventional SPECT. We evaluated the feasibility of reducing acquisition time for brain perfusion SPECT imaging using a novel CZT-based whole-body SPECT system (Discovery NM/CT 670 CZT). Methods: We enrolled a total of 30 consecutive patients (52-88 y, mean 71 y, Male 17, Female 13) who underwent 99mTc-ECD brain perfusion SPECT for evaluation of dementia. SPECT data were acquired in a list mode in 6 degree increments for 36 s/projection, resulting in a total acquisition time of 18 minutes with the 2-head camera. The acquisition data were reconstructed using 6.25%, 12.5%, 25%, 50%, and 100% of each projection data, which were equivalent to 1.1, 2.3, 4.5, 9.0, and 18 minutes acquisition, respectively. These images were automatically standardized using Q.Brain, with pixel values normalized to the individual global brain. Subsequently, we compared regional uptake ratios between 100% and each time-reduced image, and calculated Pearson correlation coefficients. Furthermore, we compared the correlation coefficients of the 100% vs each time-reduced image by Meng-Rhosenthal-Rubin Methods: Bonferroni correction was applied to minimize type I errors with multiple comparisons. Results: Injected dose of 99mTc-ECD was 824.9 ± 57.6 MBq (average ± standard deviation). Correlation coefficients of 100% vs 50%, 100% vs 25%, 100% vs 12.5%, and 100% vs 6.25% were 0.973, 0.959, 0.930, and 0.765, respectively. There was significant difference between two correlation coefficients for each comparison. Conclusion: The 50% image was most strongly correlated with the 100% image, while the 25% as well as the 12.5% images also showed very strong correlations with the 100% image. Thus, reduction in acquisition time for brain perfusion SPECT seems to be feasible using the CZT-based whole-body SPECT camera.