TY - JOUR T1 - <strong>Enhancing radiotracer development: Channel routing on ISAR without single fluid bus constraint</strong> JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 671 LP - 671 VL - 59 IS - supplement 1 AU - Christopher Frank AU - Georg Winter AU - Fredrik Rensei AU - Victor Samper AU - Peter Bartenstein AU - Allen Brooks AU - Brian Hockley AU - Bradford Henderson AU - Simon Lindner AU - Christian Rensch AU - Peter Scott Y1 - 2018/05/01 UR - http://jnm.snmjournals.org/content/59/supplement_1/671.abstract N2 - 671Objectives: Tracer development and the implementation on a synthesis module is a complex and time-intensive task. Furthermore, synthesis routines must be adapted to the synthesis platform in use. Commonly utilized single fluid bus architectures put multiple constraints on synthesis planning &amp; execution. This work shows the advantages of custom-tailored fluid paths leveraging up to 70 individually addressable valves on a chip-based consumable. Methods: The ISAR synthesis platform replaces traditional stopcock valve manifolds with a fluidic chip that integrates all fluid paths (tubing) and valves into one consumable. These fluid paths can be custom tailored for the application and utilize up to 70 membrane valves in total, without a dependency between channel routing and valve position. The basic radiochemistry techniques (e.g. azeotropic drying, hydrolysis) are developed by adapting the GE FASTlab [18F]FDG citrate process without compromising the synthesis route. In a second step [68Ga]PSMA-11 is developed on ISAR. The chip is designed for a dual run scenario with individual uncontaminated reaction structures for two runs, using only a single set of fluid containers. Based on the same principle, a 9-run scenario is applied for [13N]NH3 with a single production line for each run. Results: [18F]FDG synthesis resulted in a yield of 65% n.d.c. in less than 25 min at 47% less precursor consumption. This was achieved in 6 months development time and successfully scaled from 200 MBq to 170 GBq input activity. Based on the experience with [18F]FDG, [68Ga]PSMA-11 was synthesized on ISAR and transferred towards a dual run within a few weeks resulting in 44% n.d.c. yield in less than 11.5 min synthesis time at 50% reduced peptide consumption. Multi-run synthesis of [13N]NH3 resulted in an average yield of 96% d.c. for all 9 runs on a single chip without opening the hot cell and was accomplished within 2 weeks. Conclusion: By replacing traditional stopcock valve manifolds and tubing by a chip-based consumable, fast implementation times for radiotracer synthesis can be achieved, without major changes in the original process. Despite ISAR novelties in technical design &amp; operation, it was demonstrated that synthesis outcomes can be improved while associated production processes can be accelerated. In addition, the elimination of the single fluid bus constraint enables quick process scalability to multi-run processing. Acknowledgements: The authors gratefully acknowledge the financial support from the German Federal Ministry of Education and Research (BMBF). ER -