TY - JOUR T1 - Midbrain 18F-FP-CIT uptake in evaluation of parkinsonism JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1649 LP - 1649 VL - 59 IS - supplement 1 AU - Haejun Lee AU - Kyung-Hoon Hwang Y1 - 2018/05/01 UR - http://jnm.snmjournals.org/content/59/supplement_1/1649.abstract N2 - 1649Purpose: FP-CIT has been used in evaluation of parkinsonism basically by its uptake in dopamine transporters of striatum. It has also been known to have uptake in serotonin transporters(SERT) of midbrain, thalamus, and so on. In this study we analysed midbrain FP-CIT uptake as well as in striatum to see if midbrain uptake could be any help in differentiation of parkinsonism. Materials and methods: 18F-FP-CIT images of clinically diagnosed 47 parkinsonism patients (21 IPD, 7 MSA-P, 8 VP, 11 DIP) and 16 normal controls were analysed retrospectively. Semiquantitative binding ratios(BR) were calculated after measuring maximum and mean SUVs in striatum and midbrain. BRs of patients were compared with those of normal controls. Results: BRs for IPD and MSA-P showed statistically significant decrease in both striatum and midbrain (p<0.05), and MSA-P showed more decrease than IPD (p<0.05). BRs for VP and DIP decreased in midbrain only, not in striatum. VP showed no difference of BR in dorsal raphe of midbrain when compared with normal controls, whereas BR for DIP decreased in both subtantia nigra and dorsal raphe of midbrain. Conclusions: SERT uptake of 18F-FP-CIT in midbrain could provide additional information in evaluation of some parkinsonism. Further study with more disease groups and larger number of subjects is warranted. ER -