TY - JOUR T1 - The Preliminary results of brain<sup> 18</sup>F-FDG PET/CT-MRI coregistration in tuberous sclerosis complex with intractable epilepsy JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1670 LP - 1670 VL - 59 IS - supplement 1 AU - Yongjin Tang AU - Yong Cheng AU - Jingjie Shang AU - Bin Guo AU - Jian Gong AU - Xueying Ling AU - Lu WANG AU - Hao Xu Y1 - 2018/05/01 UR - http://jnm.snmjournals.org/content/59/supplement_1/1670.abstract N2 - 1670Introduction: BACKGROUND AND OBJECTIVE: Tuberous sclerosis complex (TSC) is an autosomal dominant disorder, often associated with cortical tubers and intractable epilepsy. The aim of this study was to analyze the image features of 18F-FDG PET/CT and PET/MRI, and to assess the application value of PET/CT-MRI coregistration in TSC with intractable epilepsy. Methods: From December 2013 to September 2017, 1325 cases of epilepsy were examined by brain 18F-FDG PET/CT and PET/MRI. Among them, 7 patients had TSC with refractory epilepsy, of whom 6 were males and 1 females, and the age was 2-16 years old. They underwent video-EEG monitoring, brain 18F-FDG PET/CT scans and 3D Bravo T1,CUBE T2 FLAIR MRI scan using the PET/CT-MRI system (GE, USA). The number of cortical and subependymal tubers was detected by CT, MRI and PET respectively, and compared the relationship between cortical tubers and epileptic activity on Video-EEG. Results: All 7 patients with focal seizure activity showed one or more lesions in the epileptic lobe. CT showed 1 cortical tubers and 28 subependymal tubers, MRI showed 80 cortical tubers and 40 subependymal tubers, PET showed 61 cortical tubers and 0 subependymal tubers. 132 cortical tubers and subependymal tubers were detected by PET/CT-MRI system. Of the 7 patients, 3 patients showed abnormal epileptic activity of the whole brain by video-EEG during the seizure period. The remaining 4 cases were used as the reference standard for the video-EEG epileptic activity in the seizure period. No cortical epileptogenic tuber was detected by CT, while 6/17 (35.3%) cortical epileptogenic tuber by MRI and 10/14 (71.4%) cortical epileptogenic tubers by PET were consistent with the epileptic activity on Video-EEG in 4 patients, respectively. In 4 patients, 24 cortical nodules were found in PET/CT-MRI. PET and MRI detected 11 cortical nodules, consistent with the epileptic activity on Video-EEG, more than PET. Conclusions: PET/CT-MR can find more intractable epilepsy patients with cortical and subcortical nodules and subependymal nodules. 18F-FDG brain PET has more advantages in the preoperative evaluation of intractable epilepsy in patients with TSC. KEYWORDS: PET/MRI , PET/CT, tuberous sclerosis complex, intractable epilepsy ER -