TY - JOUR T1 - Recent Advances in <sup>18</sup>F Radiochemistry: A Focus on B-<sup>18</sup>F, Si-<sup>18</sup>F, Al-<sup>18</sup>F, and C-<sup>18</sup>F Radiofluorination via Spirocyclic Iodonium Ylides JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 568 LP - 572 DO - 10.2967/jnumed.117.197095 VL - 59 IS - 4 AU - Vadim Bernard-Gauthier AU - Mathieu L. Lepage AU - Bjoern Waengler AU - Justin J. Bailey AU - Steven H. Liang AU - David M. Perrin AU - Neil Vasdev AU - Ralf Schirrmacher Y1 - 2018/04/01 UR - http://jnm.snmjournals.org/content/59/4/568.abstract N2 - Straightforward radiosynthesis protocols for 18F-labeled radiopharmaceuticals are an indispensable but often overlooked prerequisite to successfully perform molecular imaging studies in vivo by PET. In recent years, thanks to the expansion of the 18F chemical toolbox, structurally diverse and novel clinically relevant radiopharmaceuticals have been synthesized with both high efficiency and ready implementation. This article provides an overview of recent 18F-labeling methodologies, specifically for B-18F, Si-18F, Al-18F, and iodine (III)-mediated radiofluorination via the spirocyclic iodonium ylide technology. ER -