RT Journal Article
SR Electronic
T1 Recent Advances in <sup>18</sup>F Radiochemistry: A Focus on B-<sup>18</sup>F, Si-<sup>18</sup>F, Al-<sup>18</sup>F, and C-<sup>18</sup>F Radiofluorination via Spirocyclic Iodonium Ylides
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 568
OP 572
DO 10.2967/jnumed.117.197095
VO 59
IS 4
A1 Bernard-Gauthier, Vadim
A1 Lepage, Mathieu L.
A1 Waengler, Bjoern
A1 Bailey, Justin J.
A1 Liang, Steven H.
A1 Perrin, David M.
A1 Vasdev, Neil
A1 Schirrmacher, Ralf
YR 2018
UL http://jnm.snmjournals.org/content/59/4/568.abstract
AB Straightforward radiosynthesis protocols for 18F-labeled radiopharmaceuticals are an indispensable but often overlooked prerequisite to successfully perform molecular imaging studies in vivo by PET. In recent years, thanks to the expansion of the 18F chemical toolbox, structurally diverse and novel clinically relevant radiopharmaceuticals have been synthesized with both high efficiency and ready implementation. This article provides an overview of recent 18F-labeling methodologies, specifically for B-18F, Si-18F, Al-18F, and iodine (III)-mediated radiofluorination via the spirocyclic iodonium ylide technology.