PT  - JOURNAL ARTICLE
AU  - Vikram Adhikarla
AU  - Boadie W. Dunlop
AU  - Nashwa Jarkas
AU  - Mark M. Goodman
AU  - Helen Mayberg
AU  - Michael J. Owens
AU  - Jonathon A. Nye
TI  - Test–Retest Reliability of the SERT Imaging Agent <sup>11</sup>C-HOMADAM in Healthy Humans
AID  - 10.2967/jnumed.117.196915
DP  - 2018 Feb 01
TA  - Journal of Nuclear Medicine
PG  - 315--319
VI  - 59
IP  - 2
4099  - http://jnm.snmjournals.org/content/59/2/315.short
4100  - http://jnm.snmjournals.org/content/59/2/315.full
SO  - J Nucl Med2018 Feb 01; 59
AB  - The aim of this study was to measure the test–retest reliability of 11C-N,N-dimethyl-2-(2′-amino-4′-hydroxymethylphenylthio)benzylamine (11C-HOMADAM) imaging of serotonin transporter (SERT) density in healthy control subjects. Methods: Two female and 2 male volunteers participated in the study, with each undergoing three 90-min 11C-HOMADAM PET scans. Time–activity curves were derived from SERT-rich structures and fit to 2 models: a simplified reference tissue model and a multilinear graphical model. Binding potential, the ratio of specifically bound uptake to nondisplaceable uptake at equilibrium, was calculated from the model parameter estimates. Ninety-five percent confidence intervals and the intraclass correlation coefficient (ICC) were calculated and adjusted for repeated measures. Results: The ICC values ranged from −0.13 in the dorsal raphe to 0.88 in the caudate nucleus. The highest average ICC values were in the striatum, but other regions were sensitive to measurement outliers. Conclusion: Good-to-excellent test–retest reliability was observed for SERT binding in the striatum. The dorsal raphe ICC value was sensitive to a measurement outlier. 11C-HOMADAM binding potential calculated from the simplified reference tissue model and the multilinear graphical model were robust and in good agreement.