PT  - JOURNAL ARTICLE
AU  - Eiber, Matthias
AU  - Herrmann, Ken
AU  - Calais, Jeremie
AU  - Hadaschik, Boris
AU  - Giesel, Frederik L.
AU  - Hartenbach, Markus
AU  - Hope, Thomas
AU  - Reiter, Robert
AU  - Maurer, Tobias
AU  - Weber, Wolfgang A.
AU  - Fendler, Wolfgang P.
TI  - Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE): Proposed miTNM Classification for the Interpretation of PSMA-Ligand PET/CT
AID  - 10.2967/jnumed.117.198119
DP  - 2018 Mar 01
TA  - Journal of Nuclear Medicine
PG  - 469--478
VI  - 59
IP  - 3
4099  - http://jnm.snmjournals.org/content/59/3/469.short
4100  - http://jnm.snmjournals.org/content/59/3/469.full
SO  - J Nucl Med2018 Mar 01; 59
AB  - Prostate-specific membrane antigen (PSMA)–ligand PET imaging provides unprecedented accuracy for whole-body staging of prostate cancer. As PSMA-ligand PET/CT is increasingly adopted in clinical trials and routine practice worldwide, a unified language for image reporting is urgently needed. We propose a molecular imaging TNM system (miTNM, version 1.0) as a standardized reporting framework for PSMA-ligand PET/CT or PET/MRI. miTNM is designed to organize findings in comprehensible categories to promote the exchange of information among physicians and institutions. Additionally, flowcharts integrating findings of PSMA-ligand PET and morphologic imaging have been designed to guide image interpretation. Specific applications, such as assessment of prognosis or impact on management, should be evaluated in future trials. miTNM is a living framework that evolves with clinical experience and scientific data.