PT  - JOURNAL ARTICLE
AU  - Jae Yong Choi
AU  - Hanna Cho
AU  - Sung Jun Ahn
AU  - Jae Hoon Lee
AU  - Young Hoon Ryu
AU  - Myung Sik Lee
AU  - Chul Hyoung Lyoo
TI  - Off-Target <sup>18</sup>F-AV-1451 Binding in the Basal Ganglia Correlates with Age-Related Iron Accumulation
AID  - 10.2967/jnumed.117.195248
DP  - 2018 Jan 01
TA  - Journal of Nuclear Medicine
PG  - 117--120
VI  - 59
IP  - 1
4099  - http://jnm.snmjournals.org/content/59/1/117.short
4100  - http://jnm.snmjournals.org/content/59/1/117.full
SO  - J Nucl Med2018 Jan 01; 59
AB  - Off-target binding in the basal ganglia is commonly observed in the 18F-AV-1451 PET studies of the elderly. We sought to investigate the relationship between this phenomenon in the basal ganglia and iron accumulation using iron-sensitive R2* MRI. Methods: Fifty-nine healthy controls and 61 patients with Alzheimer disease and mild cognitive impairment underwent 18F-AV-1451 PET and R2* MRI studies. A correlation analysis was performed for age, 18F-AV-1451 binding, and R2* values. Results: There was an age-related increase in both 18F-AV-1451 binding in the basal ganglia and R2* values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. 18F-AV-1451 binding in the basal ganglia increased with R2* values. Conclusion: Off-target 18F-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation. Postmortem studies are required to further investigate the nature of this association.