TY - JOUR T1 - Optimization of SPECT Measurement of Myocardial Blood Flow with Corrections for Attenuation, Motion, and Blood Binding Compared with PET JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 2013 LP - 2019 DO - 10.2967/jnumed.117.191049 VL - 58 IS - 12 AU - R. Glenn Wells AU - Brian Marvin AU - Marlie Poirier AU - Jennifer Renaud AU - Robert A. deKemp AU - Terrence D. Ruddy Y1 - 2017/12/01 UR - http://jnm.snmjournals.org/content/58/12/2013.abstract N2 - Myocardial blood flow (MBF) and myocardial flow reserve (MFR) measured with PET have clinical value. SPECT cameras with solid-state detectors can obtain dynamic images for measurement of MBF and MFR. In this study, SPECT measurements of MBF made using 99mTc-tetrofosmin were compared with PET in the same patients. Methods: Thirty-one patients underwent PET MBF rest–stress studies performed with 82Rb or 13N-ammonia within 1 mo of their SPECT study. Dynamic rest–stress measurements were made using a SPECT camera. Kinetic parameters were calculated using a 1-tissue-compartment model and converted to MBF and MFR. Processing with and without corrections for attenuation (+AC and −AC), patient body motion (+MC and −MC), and binding of the tracer to red blood cells (+BB and −BB) was evaluated. Results: Both +BB and +MC improved the accuracy and precision of global SPECT MBF compared with PET MBF, resulting in an average difference of 0.06 ± 0.37 mL/min/g. Global MBF and detection of abnormal MFR were not significantly improved with +AC. Global SPECT MFR with +MC and +BB had an area under the receiver-operating curve of 0.90 (+AC) to 0.95 (−AC) for detecting abnormal PET MFR less than 2.0. Regional analysis produced similar results with an area under the receiver-operating curve of 0.84 (+AC) to 0.87 (−AC). Conclusion: Solid-state SPECT provides global MBF and MFR measurements that differ from PET by 2% ± 32% (MBF) and 2% ± 28% (MFR). ER -