RT Journal Article
SR Electronic
T1 Motion-Corrected Imaging of the Aortic Valve with <sup>18</sup>F-NaF PET/CT and PET/MRI: A Feasibility Study
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1811
OP 1814
DO 10.2967/jnumed.117.194597
VO 58
IS 11
A1 Doris, Mhairi K.
A1 Rubeaux, Mathieu
A1 Pawade, Tania
A1 Otaki, Yuka
A1 Xie, Yibin
A1 Li, Debiao
A1 Tamarappoo, Balaji K.
A1 Newby, David E.
A1 Berman, Daniel S.
A1 Dweck, Marc R.
A1 Slomka, Piotr J.
A1 Dey, Damini
YR 2017
UL http://jnm.snmjournals.org/content/58/11/1811.abstract
AB We investigated whether motion correction of gated 18F-fluoride PET/CT and PET/MRI of the aortic valve could improve PET quantitation and image quality. Methods: A diffeomorphic, mass-preserving, anatomy-guided registration algorithm was used to align the PET images from 4 cardiac gates, preserving all counts, and apply them to the PET/MRI and PET/CT data of 6 patients with aortic stenosis. Measured signal-to-noise ratios (SNRs) and target-to-background ratios (TBRs) were compared with the standard method of using only the diastolic gate. Results: High-intensity aortic valve 18F-fluoride uptake was observed in all patients. After motion correction, SNR and TBR increased compared with the median diastolic gate (SNR, 51.61 vs. 21.0; TBR, 2.85 vs. 2.22) and the median summed data (SNR, 51.61 vs. 34.10; TBR, 2.85 vs. 1.95) (P = 0.028 for all). Furthermore, noise decreased from 0.105 (median, diastolic) to 0.042 (median, motion-corrected) (P = 0.028). Conclusion: Motion correction of hybrid 18F-fluoride PET markedly improves SNR, resulting in improved image quality.