PT  - JOURNAL ARTICLE
AU  - Doris, Mhairi K.
AU  - Rubeaux, Mathieu
AU  - Pawade, Tania
AU  - Otaki, Yuka
AU  - Xie, Yibin
AU  - Li, Debiao
AU  - Tamarappoo, Balaji K.
AU  - Newby, David E.
AU  - Berman, Daniel S.
AU  - Dweck, Marc R.
AU  - Slomka, Piotr J.
AU  - Dey, Damini
TI  - Motion-Corrected Imaging of the Aortic Valve with <sup>18</sup>F-NaF PET/CT and PET/MRI: A Feasibility Study
AID  - 10.2967/jnumed.117.194597
DP  - 2017 Nov 01
TA  - Journal of Nuclear Medicine
PG  - 1811--1814
VI  - 58
IP  - 11
4099  - http://jnm.snmjournals.org/content/58/11/1811.short
4100  - http://jnm.snmjournals.org/content/58/11/1811.full
SO  - J Nucl Med2017 Nov 01; 58
AB  - We investigated whether motion correction of gated 18F-fluoride PET/CT and PET/MRI of the aortic valve could improve PET quantitation and image quality. Methods: A diffeomorphic, mass-preserving, anatomy-guided registration algorithm was used to align the PET images from 4 cardiac gates, preserving all counts, and apply them to the PET/MRI and PET/CT data of 6 patients with aortic stenosis. Measured signal-to-noise ratios (SNRs) and target-to-background ratios (TBRs) were compared with the standard method of using only the diastolic gate. Results: High-intensity aortic valve 18F-fluoride uptake was observed in all patients. After motion correction, SNR and TBR increased compared with the median diastolic gate (SNR, 51.61 vs. 21.0; TBR, 2.85 vs. 2.22) and the median summed data (SNR, 51.61 vs. 34.10; TBR, 2.85 vs. 1.95) (P = 0.028 for all). Furthermore, noise decreased from 0.105 (median, diastolic) to 0.042 (median, motion-corrected) (P = 0.028). Conclusion: Motion correction of hybrid 18F-fluoride PET markedly improves SNR, resulting in improved image quality.