PT - JOURNAL ARTICLE AU - Doris, Mhairi K. AU - Rubeaux, Mathieu AU - Pawade, Tania AU - Otaki, Yuka AU - Xie, Yibin AU - Li, Debiao AU - Tamarappoo, Balaji K. AU - Newby, David E. AU - Berman, Daniel S. AU - Dweck, Marc R. AU - Slomka, Piotr J. AU - Dey, Damini TI - Motion-Corrected Imaging of the Aortic Valve with <sup>18</sup>F-NaF PET/CT and PET/MRI: A Feasibility Study AID - 10.2967/jnumed.117.194597 DP - 2017 Nov 01 TA - Journal of Nuclear Medicine PG - 1811--1814 VI - 58 IP - 11 4099 - http://jnm.snmjournals.org/content/58/11/1811.short 4100 - http://jnm.snmjournals.org/content/58/11/1811.full SO - J Nucl Med2017 Nov 01; 58 AB - We investigated whether motion correction of gated 18F-fluoride PET/CT and PET/MRI of the aortic valve could improve PET quantitation and image quality. Methods: A diffeomorphic, mass-preserving, anatomy-guided registration algorithm was used to align the PET images from 4 cardiac gates, preserving all counts, and apply them to the PET/MRI and PET/CT data of 6 patients with aortic stenosis. Measured signal-to-noise ratios (SNRs) and target-to-background ratios (TBRs) were compared with the standard method of using only the diastolic gate. Results: High-intensity aortic valve 18F-fluoride uptake was observed in all patients. After motion correction, SNR and TBR increased compared with the median diastolic gate (SNR, 51.61 vs. 21.0; TBR, 2.85 vs. 2.22) and the median summed data (SNR, 51.61 vs. 34.10; TBR, 2.85 vs. 1.95) (P = 0.028 for all). Furthermore, noise decreased from 0.105 (median, diastolic) to 0.042 (median, motion-corrected) (P = 0.028). Conclusion: Motion correction of hybrid 18F-fluoride PET markedly improves SNR, resulting in improved image quality.