RT Journal Article
SR Electronic
T1 Current Concepts in <sup>68</sup>Ga-DOTATATE Imaging of Neuroendocrine Neoplasms: Interpretation, Biodistribution, Dosimetry, and Molecular Strategies
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1718
OP 1726
DO 10.2967/jnumed.116.186361
VO 58
IS 11
A1 Lisa Bodei
A1 Valentina Ambrosini
A1 Ken Herrmann
A1 Irvin Modlin
YR 2017
UL http://jnm.snmjournals.org/content/58/11/1718.abstract
AB 68Ga-DOTATATE PET/CT provides information on the location of somatostatin receptor–expressing tumors. Integrating this imaging data effectively in patient care requires the clinical history; the histopathology and biomarker information; and the grade, stage, and prior imaging results. Previous therapies and technical aspects of the study should be considered, given their ability to alter the interpretation of the images. This includes physiologic biodistribution of the radiotracer, as well as conditions that engender false-positive results. This article provides a guide to the performance and interpretation of 68Ga-DOTATATE PET/CT and describes its role in the diagnostic algorithm of neuroendocrine neoplasms and its overall utility in their management.