PT - JOURNAL ARTICLE AU - Wolfgang G. Kunz AU - Lisa M. Jungblut AU - Philipp M. Kazmierczak AU - Franziska J. Vettermann AU - Andreas Bollenbacher AU - Jörg C. Tonn AU - Christian Schichor AU - Axel Rominger AU - Nathalie L. Albert AU - Peter Bartenstein AU - Maximilian F. Reiser AU - Clemens C. Cyran TI - Improved Detection of Transosseous Meningiomas Using <sup>68</sup>Ga-DOTATATE PET/CT Compared with Contrast-Enhanced MRI AID - 10.2967/jnumed.117.191932 DP - 2017 Oct 01 TA - Journal of Nuclear Medicine PG - 1580--1587 VI - 58 IP - 10 4099 - http://jnm.snmjournals.org/content/58/10/1580.short 4100 - http://jnm.snmjournals.org/content/58/10/1580.full SO - J Nucl Med2017 Oct 01; 58 AB - 68Ga-DOTATATE PET/CT enables detection of meningioma tissue based on somatostatin receptor 2 expression. Transosseous extension of intracranial meningiomas is known to be an important risk factor for tumor recurrence and patient mortality. We analyzed the diagnostic performance of 68Ga-DOTATATE PET/CT and contrast-enhanced MRI (CE-MRI) for the detection of osseous infiltration using qualitative and quantitative imaging parameters. Methods: In this institutional review board–approved retrospective study, subjects were selected from 327 consecutive 68Ga-DOTATATE PET/CT examinations for evaluation of confirmed or suspected meningioma. Inclusion criteria were CE-MRI within 30 d and pathology-confirmed meningioma diagnosis with inclusion or exclusion of transosseous extension as the standard of reference. Imaging was analyzed by two readers. Tracer uptake values and meningioma volumes were determined. χ2, Mann–Whitney U, Wilcoxon signed rank, and McNemar tests, as well as receiver-operating-characteristic analyses, were performed to compare variables and diagnostic performance. Results: Eighty-two patients fulfilled the inclusion criteria. Patients with transosseous extension of meningioma (n = 67) showed significantly larger lesions (median, 12.8 vs. 3.3 mL; P &lt; 0.001) and significantly higher tracer uptake values (median SUVmax, 14.2 vs. 7.6; P = 0.011) than patients with extraosseous meningiomas (n = 15). 68Ga-DOTATATE PET/CT in comparison to CE-MRI performed at a higher sensitivity (98.5% vs. 53.7%) while maintaining high specificity (86.7% vs. 93.3%) in the detection of osseous involvement (P &lt; 0.001). In receiver-operating-characteristic analysis, PET/CT assessment performed better than CE-MRI (area under the curve, 0.932 vs. 0.773). PET/CT- and CE-MRI–based volume estimation yielded comparable results for extraosseous meningiomas (P = 0.132) and the extraosseous part of transosseous meningiomas (P = 0.636), whereas the volume of the intraosseous part was assessed as significantly larger by PET/CT (P &lt; 0.001). Conclusion: 68Ga-DOTATATE PET/CT enables improved detection of the transosseous extension of intracranial meningiomas compared with CE-MRI.