RT Journal Article SR Electronic T1 Cerenkov Radiation–Induced Photoimmunotherapy with 18F-FDG JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1395 OP 1400 DO 10.2967/jnumed.116.188789 VO 58 IS 9 A1 Yuko Nakamura A1 Tadanobu Nagaya A1 Kazuhide Sato A1 Shuhei Okuyama A1 Fusa Ogata A1 Karen Wong A1 Stephen Adler A1 Peter L. Choyke A1 Hisataka Kobayashi YR 2017 UL http://jnm.snmjournals.org/content/58/9/1395.abstract AB Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with toxicity induced by photoabsorbers after irradiation with NIR light. A limitation of NIR-PIT is the inability to deliver NIR light to a tumor located deep inside the body. Cerenkov radiation (CR) is the ultraviolet and blue light that is produced by a charged particle traveling through a dielectric medium faster than the speed of light in that medium and is commonly produced during radioactive decay. Here, we demonstrate the feasibility of using CR generated by 18F-FDG accumulated in tumors to induce photoimmunotherapy. Methods: Using A431-luc cells, we evaluated the therapeutic effects of CR-PIT in vitro and in vivo using bioluminescence imaging. Results: CR-PIT showed significant suppression of tumor size, but the decrease of bioluminescence after CR-PIT was not observed consistently over the entire time course. Conclusion: Although CR-PIT can induce tumor killing deep within body, it is less effective than NIR-PIT, possibly related to the relatively lower efficiency of short wavelength light than NIR.