RT Journal Article SR Electronic T1 Cerenkov Radiation–Induced Photoimmunotherapy with 18F-FDG JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1395 OP 1400 DO 10.2967/jnumed.116.188789 VO 58 IS 9 A1 Nakamura, Yuko A1 Nagaya, Tadanobu A1 Sato, Kazuhide A1 Okuyama, Shuhei A1 Ogata, Fusa A1 Wong, Karen A1 Adler, Stephen A1 Choyke, Peter L. A1 Kobayashi, Hisataka YR 2017 UL http://jnm.snmjournals.org/content/58/9/1395.abstract AB Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with toxicity induced by photoabsorbers after irradiation with NIR light. A limitation of NIR-PIT is the inability to deliver NIR light to a tumor located deep inside the body. Cerenkov radiation (CR) is the ultraviolet and blue light that is produced by a charged particle traveling through a dielectric medium faster than the speed of light in that medium and is commonly produced during radioactive decay. Here, we demonstrate the feasibility of using CR generated by 18F-FDG accumulated in tumors to induce photoimmunotherapy. Methods: Using A431-luc cells, we evaluated the therapeutic effects of CR-PIT in vitro and in vivo using bioluminescence imaging. Results: CR-PIT showed significant suppression of tumor size, but the decrease of bioluminescence after CR-PIT was not observed consistently over the entire time course. Conclusion: Although CR-PIT can induce tumor killing deep within body, it is less effective than NIR-PIT, possibly related to the relatively lower efficiency of short wavelength light than NIR.