PT  - JOURNAL ARTICLE
AU  - Nakamura, Yuko
AU  - Nagaya, Tadanobu
AU  - Sato, Kazuhide
AU  - Okuyama, Shuhei
AU  - Ogata, Fusa
AU  - Wong, Karen
AU  - Adler, Stephen
AU  - Choyke, Peter L.
AU  - Kobayashi, Hisataka
TI  - Cerenkov Radiation–Induced Photoimmunotherapy with <sup>18</sup>F-FDG
AID  - 10.2967/jnumed.116.188789
DP  - 2017 Sep 01
TA  - Journal of Nuclear Medicine
PG  - 1395--1400
VI  - 58
IP  - 9
4099  - http://jnm.snmjournals.org/content/58/9/1395.short
4100  - http://jnm.snmjournals.org/content/58/9/1395.full
SO  - J Nucl Med2017 Sep 01; 58
AB  - Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with toxicity induced by photoabsorbers after irradiation with NIR light. A limitation of NIR-PIT is the inability to deliver NIR light to a tumor located deep inside the body. Cerenkov radiation (CR) is the ultraviolet and blue light that is produced by a charged particle traveling through a dielectric medium faster than the speed of light in that medium and is commonly produced during radioactive decay. Here, we demonstrate the feasibility of using CR generated by 18F-FDG accumulated in tumors to induce photoimmunotherapy. Methods: Using A431-luc cells, we evaluated the therapeutic effects of CR-PIT in vitro and in vivo using bioluminescence imaging. Results: CR-PIT showed significant suppression of tumor size, but the decrease of bioluminescence after CR-PIT was not observed consistently over the entire time course. Conclusion: Although CR-PIT can induce tumor killing deep within body, it is less effective than NIR-PIT, possibly related to the relatively lower efficiency of short wavelength light than NIR.