PT  - JOURNAL ARTICLE
AU  - Datta, Gourab
AU  - Colasanti, Alessandro
AU  - Kalk, Nicola
AU  - Owen, David
AU  - Scott, Gregory
AU  - Rabiner, Eugenii A.
AU  - Gunn, Roger N.
AU  - Lingford-Hughes, Anne
AU  - Malik, Omar
AU  - Ciccarelli, Olga
AU  - Nicholas, Richard
AU  - Nei, Lei
AU  - Battaglini, Marco
AU  - Stefano, Nicola D.
AU  - Matthews, Paul M.
TI  - <sup>11</sup>C-PBR28 and <sup>18</sup>F-PBR111 Detect White Matter Inflammatory Heterogeneity in Multiple Sclerosis
AID  - 10.2967/jnumed.116.187161
DP  - 2017 Sep 01
TA  - Journal of Nuclear Medicine
PG  - 1477--1482
VI  - 58
IP  - 9
4099  - http://jnm.snmjournals.org/content/58/9/1477.short
4100  - http://jnm.snmjournals.org/content/58/9/1477.full
SO  - J Nucl Med2017 Sep 01; 58
AB  - The objective of this study was to assess microglial activation in lesions and in normal-appearing white matter (NAWM) of multiple sclerosis (MS) patients using PET. Methods: Thirty-four MS patients (7 with secondary progressive MS [SPMS], 27 with relapsing remitting MS [RRMS]) and 30 healthy volunteers, genetically stratified for translocator protein (TSPO) binding status, underwent PET scanning with TSPO radioligands (11C-PBR28 or 18F-PBR111). Regional TSPO availability was measured as a distribution volume ratio (DVR) relative to the caudate (a pseudoreference region). White matter lesions (WMLs) were classified as “active” (DVR highest in the lesion), “peripherally active” (perilesional DVR highest), “inactive” (DVR highest in surrounding NAWM), or “undifferentiated” (similar DVR across lesion, perilesional and NAWM volumes). Results: The mean DVR in NAWM of patients was greater than that of the healthy volunteer white matter for both radioligands. Uptake for individual WML in patients was heterogeneous, but the median WML DVR and NAWM DVR for individual patients were strongly correlated (ρ = 0.94, P = 4 × 10−11). A higher proportion of lesions were inactive in patients with SPMS (35%) than RRMS (23%), but active lesions were found in all patients, including those on highly efficacious treatments. Conclusion: TSPO radioligand uptake was increased in the brains of MS patients relative to healthy controls with 2 TSPO radiotracers. WML showed heterogeneous patterns of uptake. Active lesions were found in patients with both RRMS and SPMS. Their independent prognostic significance needs further investigation.