PT  - JOURNAL ARTICLE
AU  - O, Joo Hyun
AU  - Jacene, Heather
AU  - Luber, Brandon
AU  - Wang, Hao
AU  - Huynh, Minh-Huy
AU  - Leal, Jeffrey P.
AU  - Wahl, Richard L.
TI  - Quantitation of Cancer Treatment Response by <sup>18</sup>F-FDG PET/CT: Multicenter Assessment of Measurement Variability
AID  - 10.2967/jnumed.117.189605
DP  - 2017 Sep 01
TA  - Journal of Nuclear Medicine
PG  - 1429--1434
VI  - 58
IP  - 9
4099  - http://jnm.snmjournals.org/content/58/9/1429.short
4100  - http://jnm.snmjournals.org/content/58/9/1429.full
SO  - J Nucl Med2017 Sep 01; 58
AB  - The aim of this study was to assess the interobserver variability of quantitative 18F-FDG PET/CT parameters used in assessments of treatment response across multiple sites and readers. Methods: Paired pre- and posttreatment 18F-FDG PET/CT images of 30 oncologic patients were distributed to 22 readers across 15 U.S. and international sites. One reader was aware of the full medical history (readreference) of the patients, whereas the 21 other readers were unaware. The readers selected the single hottest tumor from each study, and made SUV measurements from this target lesion and the liver. Descriptive statistics, percentage changes in the measurements, and their agreements were obtained. Results: The intraclass correlation coefficient for the percentage change in SUVmax (%ΔSUVmax) of the hottest tumor was 0.894 (95% confidence interval [CI], 0.813–0.941), and the individual equivalence coefficient was 1.931 (95% CI, 0.568–6.449) when all reads were included (n = 638). When only the measurements that selected the same target tumor as the readreference (n = 486) were included, the intraclass correlation coefficient for the %ΔSUVmax was 0.944 (95% CI, 0.841–0.989), and the individual equivalence coefficient was −0.688 (95% CI, −1.810 to −0.092). The absolute change in SUVmean of liver corrected for lean body mass showed upper and lower limits of agreement (average bias ± 2 SDs) of 0.13 and −0.13 g/mL. Conclusion: The quantitative tumor SUV changes measured across multiple sites and readers show a high correlation. Selection of the same tumor target among readers further increased the degree of correlation.