RT Journal Article
SR Electronic
T1 <sup>18</sup>F-FDG PET/CT Optimizes Treatment in <em>Staphylococcus Aureus</em> Bacteremia and Is Associated with Reduced Mortality
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1504
OP 1510
DO 10.2967/jnumed.117.191981
VO 58
IS 9
A1 Marvin A.H. Berrevoets
A1 Ilse J.E. Kouijzer
A1 Erik H.J.G. Aarntzen
A1 Marcel J.R. Janssen
A1 Lioe-Fee De Geus-Oei
A1 Heiman F.L. Wertheim
A1 Bart-Jan Kullberg
A1 Jaap Ten Oever
A1 Wim J.G. Oyen
A1 Chantal P. Bleeker-Rovers
YR 2017
UL http://jnm.snmjournals.org/content/58/9/1504.abstract
AB Metastatic infection is an important complication of Staphylococcus aureus bacteremia (SAB). Early diagnosis of metastatic infection is crucial, because specific treatment is required. However, metastatic infection can be asymptomatic and difficult to detect. In this study, we investigated the role of 18F-FDG PET/CT in patients with SAB for detection of metastatic infection and its consequences for treatment and outcome. Methods: All patients with SAB at Radboud University Medical Center were included between January 2013 and April 2016. Clinical data and results of 18F-FDG PET/CT and other imaging techniques, including echocardiography, were collected. Primary outcomes were newly diagnosed metastatic infection by 18F-FDG PET/CT, subsequent treatment modifications, and patient outcome. Results: A total of 184 patients were included, and 18F-FDG PET/CT was performed in 105 patients, of whom 99 had a high-risk bacteremia. 18F-FDG PET/CT detected metastatic infectious foci in 73.7% of these high-risk patients. In 71.2% of patients with metastatic infection, no signs and symptoms suggesting metastatic complications were present before 18F-FDG PET/CT was performed. 18F-FDG PET/CT led to a total of 104 treatment modifications in 74 patients. Three-month mortality was higher in high-risk bacteremia patients without 18F-FDG PET/CT performed than in those in whom 18F-FDG PET/CT was performed (32.7% vs. 12.4%, P = 0.003). In multivariate analysis, 18F-FDG PET/CT was the only factor independently associated with reduced mortality (P = 0.005; odds ratio, 0.204; 95% confidence interval, 0.066–0.624). A higher comorbidity score was independently associated with increased mortality (P = 0.003; odds ratio, 1.254; 95% confidence interval, 1.078–1.457). Conclusion: 18F-FDG PET/CT is a valuable technique for early detection of metastatic infectious foci, often leading to treatment modification. Performing 18F-FDG PET/CT is associated with significantly reduced 3-mo mortality.