RT Journal Article
SR Electronic
T1 Molecular Imaging of PARP
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1025
OP 1030
DO 10.2967/jnumed.117.189936
VO 58
IS 7
A1 Brandon Carney
A1 Susanne Kossatz
A1 Thomas Reiner
YR 2017
UL http://jnm.snmjournals.org/content/58/7/1025.abstract
AB The poly(adenosine diphosphate–ribose)polymerase (PARP) family of enzymes is an important factor in the cellular DNA damage response and has gained much attention for its role in many diseases, particularly cancer. Targeted molecular imaging of PARP using fluorescent or radiolabeled tags has followed on the success of therapeutic inhibitors and gained momentum over the past few years. This review covers PARP imaging from the very first imaging agents up to the current state of the technology, with a focus on the clinical applications made possible by these agents.