RT Journal Article
SR Electronic
T1 Cumulated Activity Comparison of <sup>64</sup>Cu-/<sup>177</sup>Lu-Labeled Anti–Epidermal Growth Factor Receptor Antibody in Esophageal Squamous Cell Carcinoma Model
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 888
OP 890
DO 10.2967/jnumed.116.180521
VO 58
IS 6
A1 Eric Laffon
A1 Matthieu Thumerel
A1 Jacques Jougon
A1 Roger Marthan
YR 2017
UL http://jnm.snmjournals.org/content/58/6/888.abstract
AB This work aimed at estimating the kinetic parameters, and hence cumulated activity (AC), of a diagnostic/therapeutic convergence radiopharmaceutical, namely 64Cu-/177Lu-labeled antibody (64Cu-/177Lu-cetuximab), that acts as anti–epidermal growth factor receptor. Methods: In mice bearing esophageal squamous cell carcinoma tumors, to estimate uptake (K), release rate constant (kR), and hence AC, a kinetic model analysis was applied to recently published biodistribution data of immuno-PET imaging with 64Cu-cetuximab and of small-animal SPECT/CT imaging with 177Lu-cetuximab, including blood and TE-8 tumor. Results: K, kR, and AC were estimated to be 0.0566/0.0593 g⋅h−1⋅g−1, 0.0150/0.0030 h−1, and 2.3 × 1010/4.1 × 1012 disintegrations (per gram of TE-8 tumor), with an injected activity of 3.70/12.95 MBq, for 64Cu-/177Lu-cetuximab, respectively. Conclusion: A model is available for comparing kinetic parameters and AC of the companion diagnostic/therapeutic 64Cu-/177Lu-cetuximab that may be considered as a step for determining whether one can really use the former to predict dosimetry of the latter.