RT Journal Article
SR Electronic
T1 Using SUV<sub>max-liver</sub>-based interpretation to improve the prognostic value of early interim <sup>18</sup>F-FDG PET/CT in patients with peripheral T-cell lymphoma
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 569
OP 569
VO 58
IS supplement 1
A1 Yuewei Zhang
A1 Zhi Yang
A1 Xuejuan Wang
YR 2017
UL http://jnm.snmjournals.org/content/58/supplement_1/569.abstract
AB 569Objectives: The prognostic value of early interim 18F-FDG PET/CT (PET-2) is still controversial in patients with peripheral T-cell lymphoma (PTCL). Our previous study demonstrated the SUVmax-liver-based interpretation was a surrogate imaging interpretation for PET-2 in diffuse large B cell lymphoma (DLBCL). The purpose of this study was to investigate whether PET-2 can predict the prognosis in PTCL and the liver SUVmax (SUVmax-liver)-based interpretation could improve the outcome prediction, comparing with the Deauville five-point scale (5-PS) and the reduction rate of the maximum standardized uptake value (ΔSUVmax) criteria.Methods: 18F-FDG PET/CT after two chemotherapy cycles (PET2) were evaluated with the SUVliver-based, 5-PS, and ΔSUVmax criteria in patients with PTCL. Using the three criteria, prognostic factors were compared by the survival analysis. The cut-off value of SUVmax-liver-based interpretation was decided by area under the ROC curve. PET imaging were evaluated with the SUVmax-liver-based interpretation, 5-PS, and the ΔSUVmax criteria. Uni- and multivariate analyses of outcomes were performed using clinical variables and PET2.Results: A total of 51 patients fulfilled the inclusive criteria. The median follow-up was 14 months (range 4-67 months). We found the optimal threshold for the SUVmax-liver-based interpretation was 2.0 fold of SUVmax-liver (0.628 95%CI: 0.471-0.785). Kaplan-Meier curves demonstrated no survival statistic difference between patients with positive and negative residues, using 5-PS and the ΔSUVmax criteria. Using the SUVmax-liverx-based interpretation, the 3-year PFS was 30.0% for patients with a positive residue while 55.3% for patients with negative results (P=0.029), but the results showed no statistical difference for OS (P=0.069). Prognostic accuracies for PFS and OS were 64.71% and 70.59%. Uni- and multivariate analyses revealed that early interim PET/CT interpreted via SUVmax-liver-based criteria was the only independent predictor for PFS (P=0.025).Conclusion: Early interim 18F-FDG PET/CT can predict PFS in patients with PTCL using SUVmax-liver-based interpretation. our results need to be confirmed in controlled prospective studies involving larger patient cohorts in other multicenters in the future. Keywords: early interim positron emission tomography; peripheral T-cell lymphoma; liver SUVmax-based interpretation; prognosis Research support: Beijing Municipal Science &amp; Technology Commission; Beijing Municipal Administration of Hospitals Incubating Program (PX2017028)