TY - JOUR T1 - <strong>A Pictorial Review of Uncommon Non-oncologic Clinical Cardiovascular Applications of FDG PET-CT</strong> JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1004 LP - 1004 VL - 58 IS - supplement 1 AU - Jonathan Lam AU - Samuel Squier AU - Joseph Accurso AU - Manoj Jain AU - Akash Sharma Y1 - 2017/05/01 UR - http://jnm.snmjournals.org/content/58/supplement_1/1004.abstract N2 - 1004Objectives: 1. Review the current diagnostic role of FDG PET/CT in the diagnosis and management of non-oncologic cardiovascular disease. 2. Further describe its potential utility and indication for uncommon clinical cardiovascular applications. 3. Discuss the clinical impact of FDG PET/CT in select cases of uncommon, non-oncologic cardiovascular diseases.Methods: F18-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) has emerged as a powerful imaging tool with multiple oncologic and neurologic applications. It is also becoming established that its clinical usefulness is not limited to malignancy. More recently, its utility in inflammatory disorders has been described. We aim to highlight uncommon clinical applications for FDG PET from our clinical practice. Additionally, some normal variants will be discussed to point out important potential false positive patterns. A divisional database of cases marked as “interesting cases for follow-up” was reviewed from two tertiary referral centers. We identified several individual patients who underwent FDG PET/CT for different non-oncologic applications, of which cardiovascular indications seemed to be prominent. A targeted chart review was performed along with review of radiographic imaging to determine the clinical impact of FDG PET/CT.Results: This series of clinical cases highlights uncommon uses of FDG PET/CT studies with targeted clinical questions in some non-oncologic cardiovascular conditions including cardiac sarcoidosis, large vessel vasculitis, and implanted device infection. As an example, a 55 year old woman with suspected Takayasu’s arteritis underwent FDG PET/CT which revealed large vessel vasculitis involving the thoracoabdominal aorta, left subclavian artery, and right common iliac artery. The patient was treated with rituximab and prednisone with symptomatic improvement. A follow-up FDG PET/CT was obtained which revealed worsening extensive areas of vasculitis, despite improvement in symptoms. This resulted in a change of clinical management with discontinuation of rituximab and initiation of tocilizumab.Conclusion: FDG PET/CT has several non-oncologic clinical cardiovascular applications and can be utilized to help diagnose and monitor treatment response. ER -