RT Journal Article SR Electronic T1 The maximal standardized uptake value of F-18 FDG PET/CT is positively correlated with the nuclear grading of clear cell renal cell carcinoma JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 752 OP 752 VO 58 IS supplement 1 A1 Zhanli Fu A1 Wei Li A1 Jianhua Zhang A1 Xueqi Chen YR 2017 UL http://jnm.snmjournals.org/content/58/supplement_1/752.abstract AB 752Objectives: To evaluate the relationship between the maximum standardized uptake value (SUVmax) of F-18 FDG PET/CT and nuclear grading of clear cell renal cell carcinoma (CCRCC).Methods: We retrospectively identified 41 patients who underwent 18F-FDG PET/CT during 2014 to 2016 and pathologically diagnosed as CCRCC. The relationships of the SUVmax with nuclear grading, tumor size (maximum dimension), necrosis, metastasis and other variables, such as patient’s age, sex, location of the involved kidney, blood glucose level, and uptake interval between F-18 FDG injection and PET/CT scanning, were investigated.Results: A total of 41 patients (24 males, 17 females, aged 56.4±11.6 years) with 41 CCRCCs (20 left-sided, 21 right-sided, tumor sized 76.9±36.4 mm) was include in this study. Ten patients (24%) had outside-kidney metastases. The blood glucose level and F-18 FDG uptake interval was 6.2±1.1 mmol/L and 62.6±14.9 minutes, respectively. Forty-one CCRCCs were pathologically graded as G1 in 10 patients, G2 in 21 patients, G3 in 9 patients, and G4 in 1 patient. The corresponding SUVmax in the G1 to G4 subgroup was 3.93±3.52, 5.32±2.92, 10.18±4.62, and 7.60, respectively. There was a statistically positive correlation of SUVmax with nuclear grading (R=0.54), tumor size (R=0.49), metastasis (R=0.38), and tumor necrosis (R=0.33). There was no statistically significant correlation of SUVmax with patient’s age, sex, location of the involved kidney, blood glucose level, and F-18 FDG uptake interval.Conclusion: The SUVmax of F-18 FDG PET/CT is correlated with nuclear grading, tumor size, metastasis and necrosis, which may provide valuable information of prognosis for patients with CCRCC. Research Support: No