PT  - JOURNAL ARTICLE
AU  - Brennan J. Wadsworth
AU  - Jinhe Pan
AU  - Iulia Dude
AU  - Nadine Colpo
AU  - Momir Bosiljcic
AU  - Kuo-Shyan Lin
AU  - Francois Benard
AU  - Kevin L Bennewith
TI  - 2-<sup>18</sup>F-Fluoroethanol Is a PET Reporter of Solid Tumor Perfusion
AID  - 10.2967/jnumed.116.183624
DP  - 2017 May 01
TA  - Journal of Nuclear Medicine
PG  - 815--820
VI  - 58
IP  - 5
4099  - http://jnm.snmjournals.org/content/58/5/815.short
4100  - http://jnm.snmjournals.org/content/58/5/815.full
SO  - J Nucl Med2017 May 01; 58
AB  - Solid tumor perfusion is a proven variable of interest for predicting cancer aggression and response to therapy. Current methods for noninvasively imaging tumor perfusion with PET are limited by restricted accessibility and short half-lives of perfusion radiotracers. This study presents 2-18F-fluoroethanol (2-18F-FEtOH) as a perfusion reporter that can distinguish between tumors of varying perfusion levels and can be applied to screening drugs that modify tumor perfusion. Methods: Uptake of 2-18F-FEtOH in 4T1 and 67NR murine mammary carcinoma tumors grown in mice was measured using ex vivo radiography as well as static and dynamic PET imaging. 2-18F-FEtOH uptake was directly compared with the 14C-iodoantipyrine perfusion reporter, and the perfusion-modifying drugs nicotinamide, pentoxifylline, and hydralazine were used to manipulate tumor perfusion before 2-18F-FEtOH quantification. Results: Uptake of 2-18F-FEtOH in 4T1 and 67NR tumors was consistent with known perfusion differences within and between these tumors. 2-18F-FEtOH uptake corresponded well with 14C-iodoantipyrine and reflected the tumor perfusion-modifying effects of each drug. Conclusion: 2-18F-FEtOH is a novel 18F-based radiotracer for investigating tumor perfusion with PET imaging. Quantification of 2-18F-FEtOH uptake can be used to distinguish between tumors of varying perfusion and to screen the efficacy of blood flow–modifying drugs for use as adjuvants to existing cancer therapies.