PT - JOURNAL ARTICLE AU - Amanda J. Youker AU - Sergey D. Chemerisov AU - Peter Tkac AU - Michael Kalensky AU - Thad A. Heltemes AU - David A. Rotsch AU - George F. Vandegrift AU - John F. Krebs AU - Vakho Makarashvili AU - Dominique C. Stepinski TI - Fission-Produced <sup>99</sup>Mo Without a Nuclear Reactor AID - 10.2967/jnumed.116.181040 DP - 2017 Mar 01 TA - Journal of Nuclear Medicine PG - 514--517 VI - 58 IP - 3 4099 - http://jnm.snmjournals.org/content/58/3/514.short 4100 - http://jnm.snmjournals.org/content/58/3/514.full SO - J Nucl Med2017 Mar 01; 58 AB - 99Mo, the parent of the widely used medical isotope 99mTc, is currently produced by irradiation of enriched uranium in nuclear reactors. The supply of this isotope is encumbered by the aging of these reactors and concerns about international transportation and nuclear proliferation. Methods: We report results for the production of 99Mo from the accelerator-driven subcritical fission of an aqueous solution containing low enriched uranium. The predominately fast neutrons generated by impinging high-energy electrons onto a tantalum convertor are moderated to thermal energies to increase fission processes. The separation, recovery, and purification of 99Mo were demonstrated using a recycled uranyl sulfate solution. Conclusion: The 99Mo yield and purity were found to be unaffected by reuse of the previously irradiated and processed uranyl sulfate solution. Results from a 51.8-GBq 99Mo production run are presented.