TY - JOUR T1 - Diabetes Mellitus and Its Effects on All-Cause Mortality After Radiopeptide Therapy for Neuroendocrine Tumors JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 97 LP - 102 DO - 10.2967/jnumed.116.180687 VL - 58 IS - 1 AU - Maria Umlauft AU - Piotr Radojewski AU - Petar-Marko Spanjol AU - Rebecca Dumont AU - Nicolas Marincek AU - Attila Kollar AU - Philippe Brunner AU - Jan Beyersmann AU - Jan Müller-Brand AU - Helmut R. Maecke AU - Markus Laimer AU - Martin A. Walter Y1 - 2017/01/01 UR - http://jnm.snmjournals.org/content/58/1/97.abstract N2 - We aimed to assess the risk of developing diabetes mellitus and its effects on all-cause mortality after radiopeptide therapy for neuroendocrine tumors (NETs). Methods: NET patients received somatostatin radiopeptide therapy with 90Y-DOTATOC or 177Lu-DOTATOC. The incidence of diabetes mellitus and its mortality were assessed using univariate and multivariate regression. Results: Overall, 1,535 NET patients were enrolled and received 3,807 treatment cycles. After treatment, 72 patients developed diabetes mellitus, including 47 cases after 90Y-DOTATOC and 25 cases after combined treatment. The diabetes mellitus risk was higher before than after DOTATOC (estimate, 0.0032; P < 0.001), and overall survival was similar in patients with and without diabetes mellitus (hazard ratio, 1.13; 95% confidence interval, 0.91–1.39; n = 1,535; P = 0.27). Conclusion: Radiopeptide therapy does not appear to increase the risk of developing diabetes mellitus in NET patients, whereas diabetes mellitus does not appear to increase the mortality of NET patients undergoing receptor-targeted radiopeptide therapy. ER -