TY - JOUR T1 - Prognostic value of combined [99m]Tc-MAA-SPECT/CT and [18F]Fluoroethylcholine-PET/CT in patients suffering from advanced hepatocellular carcinoma prior to radioembolization JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 2712a LP - 2712a VL - 57 IS - supplement 2 AU - Alexander Haug AU - Stefan Weber AU - Sabrina Hartenbach AU - Mathias Zacherl AU - Philipp Paprottka AU - Reinhold Tiling AU - Peter Bartenstein AU - Marcus Hacker AU - Nathalie Albert AU - Markus Hartenbach Y1 - 2016/05/01 UR - http://jnm.snmjournals.org/content/57/supplement_2/2712a.abstract N2 - 2712aObjectives Hepatocellular carcinomas (HCC) are increasingly treated with radioembolization (RE). However, prognostic factors with regard to survival are needed for better patient selection.Methods 24 patients with advanced HCC underwent MAA-SPECT/CT und FEC-PET/CT prior to RE. We evaluated various uptake parameters, tumor-to-spleen-ratio and volumetric overlap of uptake on MAA-SPECT/CT and FEC-PET/CT using Hermes Hybrid 3D viewer. This data was analyzed with regard to survival. We used ROC analysis, Youden-index, multiple logistic regression analysis and Kaplan-Meier analysis for statistical analysis.Results All patients died with a median survival of 437±71 days. A high overlap of MAA SPECT/CT and FEC PET/CT was significantly associated with a shorter survival (AUC=0,75; P<0,05). A combination of SUV values, tumor-to-spleen-ratio and volumetric data using multiple logistic regression had an AUC of 0.87 (P=0.004) with a sensitivity of 100%, specificity of 75%, accuracy of 92%, a NPV of 89% and a PPV of 100% (P<0.001). Regression analysis was able to separate patients with regard to prognosis (median survival 531±68 days versus 840±96 days; log rank: 5.7; P=0.017).Conclusions Patients suffering from advanced HCC and a combination of high overlap of MAA-uptake (as a parameter for high tumor vascularization) and FEC-uptake have a significantly shorter survival as the remaining patients. This finding may aid to enhanced patient selection for RE. ER -