RT Journal Article
SR Electronic
T1 In Vivo Dynamic Metabolic Changes After Transplantation of Induced Pluripotent Stem Cells for Ischemic Injury
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 2012
OP 2015
DO 10.2967/jnumed.115.171124
VO 57
IS 12
A1 Shuang Wu
A1 Yuankai Zhu
A1 Hao Liu
A1 Ling Tang
A1 Ruili Du
A1 Yehua Shen
A1 Jin Feng
A1 Kai Zhang
A1 Caiyun Xu
A1 Shouhong Zhang
A1 Yao Chen
A1 Fahuan Song
A1 Yunqi Zhu
A1 Weizhong Gu
A1 Ping Liang
A1 Ignasi Carrió
A1 Hong Zhang
A1 Mei Tian
YR 2016
UL http://jnm.snmjournals.org/content/57/12/2012.abstract
AB This study aimed to investigate in vivo dynamic metabolic changes after transplantation of induced pluripotent stem cells (iPSCs) and iPSC-derived enriched cardiomyocytes (iPSC-CMs) in a rat model of ischemic injury. Methods: Serial 18F-FDG PET, echocardiographic, immunohistochemical, and immunofluorescence studies were performed after transplantation of iPSCs and iPSC-CMs and compared with embryonic stem cells (ESCs), ESC-CMs, and a phosphate-buffered saline control group of rats with myocardial infarction. Results: Increased glucose metabolism in periinfarct areas and improved myocardial function were observed in the stem cell transplantation groups compared with the control group, and serial immunofluorescence and immunohistochemical results exhibited the survival and migration of stem cells during the study period. Conclusion: Serial 18F-FDG PET and echocardiographic imaging studies demonstrated the dynamic metabolic changes and recovery of myocardial function after stem cell transplantation. 18F-FDG PET could be a potential approach to evaluating spatiotemporal dynamic metabolic changes in vivo after transplantation of iPSCs or iPSC-CMs for ischemic injury.