TY - JOUR T1 - PET Mapping of Neurofunctional Changes in a Posttraumatic Stress Disorder Model JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1474 LP - 1477 DO - 10.2967/jnumed.116.173443 VL - 57 IS - 9 AU - Yunqi Zhu AU - Ruili Du AU - Yuankai Zhu AU - Yehua Shen AU - Kai Zhang AU - Yao Chen AU - Fahuan Song AU - Shuang Wu AU - Hong Zhang AU - Mei Tian Y1 - 2016/09/01 UR - http://jnm.snmjournals.org/content/57/9/1474.abstract N2 - Posttraumatic stress disorder (PTSD) is an anxiety disorder that occurs after exposure to a traumatic event. This study aimed to investigate the neurobiologic changes before and after exposure-based therapy by PET in a rat model of PTSD. Methods: Serial 18F-FDG PET imaging studies were performed under the control (tone presentation), fear-conditioning, and extinction retrieval phases. Neuroactivity marker c-Fos protein was used for immunostaining. Results: Increased glucose metabolism was observed in the bilateral amygdala after fear-conditioning (P < 0.001) and in the right posterior insular cortex under extinction retrieval (P < 0.001) compared with the control phase. Increased c-Fos expression in the posterior insular cortex under extinction retrieval was positively correlated to the glucose metabolism (P < 0.01). Conclusion: Our results indicated that the amygdala plays a key role in fear memory formation and, most importantly, the insular cortex is related to the retrieval of extinction memory. 18F-FDG PET may provide a promising in vivo approach for evaluating exposure-based therapy of PTSD. ER -