PT  - JOURNAL ARTICLE
AU  - Yunqi Zhu
AU  - Ruili Du
AU  - Yuankai Zhu
AU  - Yehua Shen
AU  - Kai Zhang
AU  - Yao Chen
AU  - Fahuan Song
AU  - Shuang Wu
AU  - Hong Zhang
AU  - Mei Tian
TI  - PET Mapping of Neurofunctional Changes in a Posttraumatic Stress Disorder Model
AID  - 10.2967/jnumed.116.173443
DP  - 2016 Sep 01
TA  - Journal of Nuclear Medicine
PG  - 1474--1477
VI  - 57
IP  - 9
4099  - http://jnm.snmjournals.org/content/57/9/1474.short
4100  - http://jnm.snmjournals.org/content/57/9/1474.full
SO  - J Nucl Med2016 Sep 01; 57
AB  - Posttraumatic stress disorder (PTSD) is an anxiety disorder that occurs after exposure to a traumatic event. This study aimed to investigate the neurobiologic changes before and after exposure-based therapy by PET in a rat model of PTSD. Methods: Serial 18F-FDG PET imaging studies were performed under the control (tone presentation), fear-conditioning, and extinction retrieval phases. Neuroactivity marker c-Fos protein was used for immunostaining. Results: Increased glucose metabolism was observed in the bilateral amygdala after fear-conditioning (P < 0.001) and in the right posterior insular cortex under extinction retrieval (P < 0.001) compared with the control phase. Increased c-Fos expression in the posterior insular cortex under extinction retrieval was positively correlated to the glucose metabolism (P < 0.01). Conclusion: Our results indicated that the amygdala plays a key role in fear memory formation and, most importantly, the insular cortex is related to the retrieval of extinction memory. 18F-FDG PET may provide a promising in vivo approach for evaluating exposure-based therapy of PTSD.