RT Journal Article SR Electronic T1 Cardiac Amyloid Imaging with 18F-Florbetaben PET: A Pilot Study JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1733 OP 1739 DO 10.2967/jnumed.115.169870 VO 57 IS 11 A1 W. Phillip Law A1 William Y.S. Wang A1 Peter T. Moore A1 Peter N. Mollee A1 Arnold C.T. Ng YR 2016 UL http://jnm.snmjournals.org/content/57/11/1733.abstract AB Our aim was to determine the feasibility of 18F-florbetaben PET in diagnosing cardiac amyloidosis. Methods: 18F-florbetaben PET was performed on 14 patients: 5 amyloid light chain, 5 amyloid transthyretin, and 4 control with hypertensive heart disease. Qualitative and quantitative assessments of 18F-florbetaben activity were performed using the SUVmean of the left ventricular myocardium and blood pool and calculation of target-to-background SUV ratio. Myocardial 18F-forbetaben retention was also calculated as the percentage mean myocardial SUV change between 0 and 5 min and 15 and 20 min after radiotracer injection. Global left ventricular longitudinal and right ventricular free wall longitudinal strain were calculated using 2-dimensional speckle-tracking echocardiography. Results: Target-to-background SUV ratio and percentage myocardial 18F-forbetaben retention were higher in amyloid patients than in hypertensive controls. A cutoff of 40% was able to differentiate between cardiac amyloid patients and hypertensive controls. Percentage myocardial 18F-forbetaben retention was an independent determinant of both global left ventricular longitudinal and right ventricular free wall longitudinal strain via an inverse curve relationship. Conclusion: 18F-florbetaben PET imaging can accurately identify and differentiate between cardiac amyloidosis and hypertensive heart disease. Percentage myocardial 18F-florbetaben retention was an independent determinant of myocardial dysfunction in cardiac amyloidosis.