RT Journal Article
SR Electronic
T1 Precision Nanomedicine Using Dual PET and MR Temperature Imaging–Guided Photothermal Therapy
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1778
OP 1783
DO 10.2967/jnumed.116.172775
VO 57
IS 11
A1 Min Zhou
A1 Marites Melancon
A1 R. Jason Stafford
A1 Junjie Li
A1 Alpa M. Nick
A1 Mei Tian
A1 Anil K. Sood
A1 Chun Li
YR 2016
UL http://jnm.snmjournals.org/content/57/11/1778.abstract
AB Imaging-based techniques have enabled the direct integration of noninvasive imaging with minimally invasive interventions such as photothermal therapy (PTT) to improve the precision of treatment. Methods: We investigated the feasibility of PTT for ovarian cancer under the guidance of PET and MR temperature imaging using copper sulfide nanoparticles (CuS NPs). The tumor distribution of the CuS NPs after systemic administration was assessed using highly sensitive, quantifiable PET imaging. Two wavelengths of near-infrared (NIR) lasers—808 and 980 nm—were tested for PTT using noninvasive MR temperature imaging real-time monitoring. Results: The in vivo studies revealed that the 980-nm NIR laser had better photothermal effects than the 808-nm NIR laser. These results were in accord with the histologic findings. In vivo PTT using CuS NPs combined with 980-nm laser irradiation achieved significant tumor ablation compared with no treatment control in both subcutaneous (P = 0.007) and orthotopic (P < 0.001) models of ovarian cancer with regard to the percentage of necrotic damage. Conclusion: Our results indicate that real-time monitoring of the accuracy of PTT is a promising approach for future clinical translation of this emerging thermal ablation technique.