PT  - JOURNAL ARTICLE
AU  - Golla, Sandeep S.V.
AU  - Boellaard, Ronald
AU  - Oikonen, Vesa
AU  - Hoffmann, Anja
AU  - van Berckel, Bart N.M.
AU  - Windhorst, Albert D.
AU  - Virta, Jere
AU  - te Beek, Erik T.
AU  - Groeneveld, Geert Jan
AU  - Haaparanta-Solin, Merja
AU  - Luoto, Pauliina
AU  - Savisto, Nina
AU  - Solin, Olof
AU  - Valencia, Ray
AU  - Thiele, Andrea
AU  - Eriksson, Jonas
AU  - Schuit, Robert C.
AU  - Lammertsma, Adriaan A.
AU  - Rinne, Juha O.
TI  - Parametric Binding Images of the TSPO Ligand <sup>18</sup>F-DPA-714
AID  - 10.2967/jnumed.116.173013
DP  - 2016 Oct 01
TA  - Journal of Nuclear Medicine
PG  - 1543--1547
VI  - 57
IP  - 10
4099  - http://jnm.snmjournals.org/content/57/10/1543.short
4100  - http://jnm.snmjournals.org/content/57/10/1543.full
SO  - J Nucl Med2016 Oct 01; 57
AB  - 18F-labeled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-yl)acetamide (DPA-714) is a radioligand for the 18-kDa translocator protein. The purpose of the present study was to identify the best method for generating quantitative parametric images of 18F-DPA-714 binding. Methods: Ninety-minute dynamic 18F-DPA-714 PET scans with full arterial sampling from 6 healthy subjects and 9 Alzheimer disease (AD) patients were used. Plasma-input–based Logan graphical analysis and spectral analysis were used to generate parametric volume of distribution (VT) images. Five versions of Ichise, reference Logan, and 2 basis function implementations (receptor parametric mapping and simplified reference tissue model 2 [SRTM2]) of SRTM, all using gray matter cerebellum as the reference region, were applied to generate nondisplaceable binding potential (BPND) images. Results: Plasma-input Logan analysis (r2 = 0.99; slope, 0.88) and spectral analysis (r2 = 0.99, slope, 0.93) generated estimates of VT that correlated well with values obtained using nonlinear regression. BPND values generated using SRTM2 (r2 = 0.83; slope, 0.95) and reference Logan analysis (r2 = 0.88; slope, 1.01) correlated well with nonlinear regression–based estimates. Conclusion: Both Logan analysis and spectral analysis can be used to obtain quantitatively accurate VT images of 18F-DPA-714. In addition, SRTM2 and reference Logan analysis can provide accurate BPND images. These parametric images could be used for voxel-based comparisons.