PT - JOURNAL ARTICLE AU - Walter Jentzen AU - Femke Verschure AU - Annelie van Zon AU - Rudie van de Kolk AU - Roel Wierts AU - Jochen Schmitz AU - Andreas Bockisch AU - Ina Binse TI - <sup>124</sup>I PET Assessment of Response of Bone Metastases to Initial Radioiodine Treatment of Differentiated Thyroid Cancer AID - 10.2967/jnumed.115.170571 DP - 2016 Oct 01 TA - Journal of Nuclear Medicine PG - 1499--1504 VI - 57 IP - 10 4099 - http://jnm.snmjournals.org/content/57/10/1499.short 4100 - http://jnm.snmjournals.org/content/57/10/1499.full SO - J Nucl Med2016 Oct 01; 57 AB - Iodine-positive bone metastases (BMs) are often resistant after initial radioiodine therapy applying the standard-activity approach. A comprehensive lesion-based response study for BMs has not, to our knowledge, yet been performed. In this study, pretherapy and follow-up 124I PET/CT data on BMs from differentiated thyroid cancer patients were retrospectively analyzed to assess the relationship between absorbed dose (AD) of radiation and response after initial radioiodine treatment. Methods: Before and after initial radioiodine therapy, patients underwent serial PET/CT scanning after administration of 20–40 MBq of 124I. The pretherapy PET data were used to segment BM volumes and to predict the average ADs after administration of dosimetry-guided 131I activity. The lower volume limit of determinability of the applied segmentation method was a sphere volume of 0.16 mL. This volume limit classified the BMs into known-volume and fixed-volume groups with their respective average and minimum ADs. Follow-up 124I and 18F-FDG PET/CT data after treatment were analyzed to assess lesion-based therapy response. Response rates at different AD thresholds were calculated and were expressed as the percentage of completely responding BMs above the respective AD threshold. BMs with a maximum extent greater than twice the PET spatial resolution were visually scored for nonuniformity. Results: In total, 61 BMs in 10 patients were included, of which 46 and 15 comprised the known-volume group and the fixed-volume group, respectively. The median follow-up time was 5.6 mo (range, 3.7–23.2 mo). The median average and median minimum ADs in therapy were 183 Gy (range, 39–3,600 Gy) and 270 Gy (range, 63–1,300 Gy), respectively. A range of response rate of 70%–80% was achieved at an AD threshold range of 350–650 Gy. There were 26 BMs that were amenable to visual assessment of nonuniformity, of which two thirds (17/26) were scored as clearly nonuniform, and the majority (11/17) of these nonuniform BMs responded incompletely. Conclusion: Both the high AD threshold associated with high response rates and the low median AD per unit of 131I activity elucidate the difficulty in achieving therapeutic efficacy for BMs when a single standard activity is administered. The relatively high AD threshold range is possibly a result of distinct levels of spatial nonuniformity in ADs.