RT Journal Article
SR Electronic
T1 Toward (Hybrid) Navigation of a Fluorescence Camera in an Open Surgery Setting
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1650
OP 1653
DO 10.2967/jnumed.115.171645
VO 57
IS 10
A1 Gijs H. KleinJan
A1 Nynke S. van den Berg
A1 Matthias N. van Oosterom
A1 Thomas Wendler
A1 Mitsuharu Miwa
A1 Axel Bex
A1 Kees Hendricksen
A1 Simon Horenblas
A1 Fijs W.B. van Leeuwen
YR 2016
UL http://jnm.snmjournals.org/content/57/10/1650.abstract
AB With the introduction of the hybrid tracer indocyanine green (ICG)-99mTc-nanocolloid, a direct relation between preoperative imaging and intraoperative fluorescence guidance was established. However, fluorescence guidance remains limited by its superficial nature. This study evaluated the feasibility of a nuclear medicine–based navigation concept that allowed intraoperative positioning of a fluorescence camera (FC) in the vicinity of preoperatively defined ICG-99mTc-nanocolloid containing sentinel nodes (SNs). Methods: Five patients with penile cancer scheduled for SN biopsy were injected with ICG-99mTc-nanocolloid followed by preoperative SPECT/CT imaging. The navigation device was used to provide a real-time augmented reality overlay of the SPECT/CT images and video output of the FC. This overlay was then used for FC navigation. Results: SPECT/CT identified 13 SNs in 9 groins. FC navigation was successful for all 12 intraoperatively evaluated SNs (average error, 8.8 mm; range, 0–20 mm). Conclusion: This study reveals the potential benefits of FC navigation during open surgery procedures.