PT  - JOURNAL ARTICLE
AU  - Mateen C. Moghbel
AU  - Lale Kostakoglu
AU  - Katherine Zukotynski
AU  - Delphine L. Chen
AU  - Helen Nadel
AU  - Ryan Niederkohr
AU  - Erik Mittra
TI  - Response Assessment Criteria and Their Applications in Lymphoma: Part 1
AID  - 10.2967/jnumed.115.166280
DP  - 2016 Jun 01
TA  - Journal of Nuclear Medicine
PG  - 928--935
VI  - 57
IP  - 6
4099  - http://jnm.snmjournals.org/content/57/6/928.short
4100  - http://jnm.snmjournals.org/content/57/6/928.full
SO  - J Nucl Med2016 Jun 01; 57
AB  - The effectiveness of cancer therapy, both in individual patients and across populations, requires a systematic and reproducible method for evaluating response to treatment. Early efforts to meet this need resulted in the creation of numerous guidelines for quantifying posttherapy changes in disease extent, both anatomically and metabolically. Over the past few years, criteria for disease response classification have been developed for specific cancer histologies. To date, the spectrum of disease broadly referred to as lymphoma is perhaps the most common for which disease response classification is used. This review article provides an overview of the existing response assessment criteria for lymphoma and highlights their respective methodologies and validities. Concerns over the technical complexity and arbitrary thresholds of many of these criteria, which have impeded the long-standing endeavor of standardizing response assessment, are also discussed.