PT - JOURNAL ARTICLE AU - Vikram Rao Bollineni AU - Sigmund Ytre-Hauge AU - Oksana Bollineni-Balabay AU - Helga Birgitte Salvesen AU - Ingfrid Salvesen Haldorsen TI - High Diagnostic Value of <sup>18</sup>F-FDG PET/CT in Endometrial Cancer: Systematic Review and Meta-Analysis of the Literature AID - 10.2967/jnumed.115.170597 DP - 2016 Jun 01 TA - Journal of Nuclear Medicine PG - 879--885 VI - 57 IP - 6 4099 - http://jnm.snmjournals.org/content/57/6/879.short 4100 - http://jnm.snmjournals.org/content/57/6/879.full SO - J Nucl Med2016 Jun 01; 57 AB - The aim of this study was to evaluate the diagnostic performance of 18F-FDG PET/CT for the preoperative assessment of lymph node metastases (LNM) in endometrial cancer patients and for the assessment of endometrial cancer recurrence (ECR) after primary surgical treatment. Methods: A comprehensive search was performed on Pubmed/MEDLINE databases for studies reporting the diagnostic performance of 18F-FDG PET/CT for assessment of LNM and ECR published up to August 15, 2015. Twenty-one studies (13 for LNM and 8 for ECR) were included in the systematic review and meta-analysis. Pooled estimates of sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio of the 18F-FDG PET/CT were calculated along with 95% confidence intervals (CIs). A summary receiver-operating-characteristics curve (SROC) was constructed, and the area under the SROC curve (AUC) was determined along with Q* index. Results: The overall pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and AUC (with 95% CI) of 18F-FDG PET/CT for detection of LNM were 0.72 (95% CI, 0.63–0.80), 0.94 (95% CI, 0.93–0.96), 10.9 (95% CI, 7.9–15.1), 0.36 (95% CI, 0.27–0.48), 39.7 (95% CI, 21.4–73.6), and 0.94 (95% CI, 0.85–0.99), respectively, whereas the corresponding numbers for detection of ECR were 0.95 (95% CI, 0.91–0.98), 0.91 (95% CI, 0.86–0.94), 8.8 (95% CI, 6.0–12.7), 0.08 (95% CI, 0.05–0.15), 171.7 (95% CI, 67.9–434.3), and 0.97 (95% CI, 0.95–0.98), respectively. The overall diagnostic accuracy (Q* index) in LNM and ECR were 0.88 and 0.93, respectively. Conclusion: 18F-FDG PET/CT has an excellent diagnostic performance for detecting LNM preoperatively and disease recurrence postoperatively in endometrial cancer patients.