RT Journal Article SR Electronic T1 Anlysis of clinical factors related with successful ablation following rhTSH aided radioiodine ablation for well differentiated thyroid cancer. JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1449 OP 1449 VO 57 IS supplement 2 A1 Yun Soo Park A1 Seok Mo Lee A1 Ji Sun Park A1 Kyung Pyo Jung A1 Su Jung Choi A1 Sun Seong Lee YR 2016 UL http://jnm.snmjournals.org/content/57/supplement_2/1449.abstract AB 1449Objectives Recently, Recombinant Human TSH (rhTSH) is being used to prepare patient for radiometabolic treatment of iodine-avid metastases or remnant thyroid tissue from differentiated thyroid cancer. We evaluate which factor has the impact of successful ablation rate in patients who had rhTSH aided radioiodine ablation.Methods Ninety-two patients who underwent rhTSH aided radioiodine ablation after total thyroidectomy were enrolled in this study. We evaluate several factors including gender, age, therapeutic dose, weight, Body Mass Index (BMI), Lean Body Mass (LBM), nodule size, multiplicity, extracapsular invasion, lymph node metastasis, surgical margin invasion, stimulated serum Tg (sTg) titer, pretreatment BUN, Cr and liver enzyme levels. Successful ablation was determined by criteria of dynamic risk stratification. Receiver operating characteristic curves (ROC) analysis was adopted to determine the cutoff value for the predictors. Univariate and multivariate logistic regression analysis were used to analyze the correlation between these clinical factors and successful ablation.Results In univariate analysis, six factors including age (&#8804;48 years, OR 4.49, 95% CI 1.20-16.81, P = 0.03), LBM (>43.3 kg, OR 5.88, 95% CI 1.56-25.00, P = 0.01), sTg (&#8804;1.69 ng/mL, OR 4.92, 95% CI 1.66-14.60, P = 0.004), BUN (&#8804;11.8 mg/dL, OR 4.24, 95% CI 1.45-12.46, P = 0.01), ALP (&#8804;261 IU/L, OR 8.25, 95% CI 2.54-26.85, P < 0.01) were significantly associated with successful ablation. In multivariate analysis, LBM (OR 0.05, 95% CI 0.01-0.38, P = 0.03), BUN (OR 6.01, 95% CI 1.36-26.62, P = 0.02) and ALP (OR 16.86, 95% CI 2.68-106.15, P < 0.01) showed significant association with successful ablation.Conclusions According to our result, LBM (>43.3 kg), BUN (&#8804;11.8 mg/dL) and ALP (&#8804;261 IU/L) were significantly correlated with successful ablation in rhTSH aided radioiodine therapy for differentiated thyroid cancer.