PT  - JOURNAL ARTICLE
AU  - Yun Soo Park
AU  - Seok Mo Lee
AU  - Ji Sun Park
AU  - Kyung Pyo Jung
AU  - Su Jung Choi
AU  - Sun Seong Lee
TI  - Anlysis of clinical factors related with successful ablation following rhTSH aided radioiodine ablation for well differentiated thyroid cancer.
DP  - 2016 May 01
TA  - Journal of Nuclear Medicine
PG  - 1449--1449
VI  - 57
IP  - supplement 2
4099  - http://jnm.snmjournals.org/content/57/supplement_2/1449.short
4100  - http://jnm.snmjournals.org/content/57/supplement_2/1449.full
SO  - J Nucl Med2016 May 01; 57
AB  - 1449Objectives Recently, Recombinant Human TSH (rhTSH) is being used to prepare patient for radiometabolic treatment of iodine-avid metastases or remnant thyroid tissue from differentiated thyroid cancer. We evaluate which factor has the impact of successful ablation rate in patients who had rhTSH aided radioiodine ablation.Methods Ninety-two patients who underwent rhTSH aided radioiodine ablation after total thyroidectomy were enrolled in this study. We evaluate several factors including gender, age, therapeutic dose, weight, Body Mass Index (BMI), Lean Body Mass (LBM), nodule size, multiplicity, extracapsular invasion, lymph node metastasis, surgical margin invasion, stimulated serum Tg (sTg) titer, pretreatment BUN, Cr and liver enzyme levels. Successful ablation was determined by criteria of dynamic risk stratification. Receiver operating characteristic curves (ROC) analysis was adopted to determine the cutoff value for the predictors. Univariate and multivariate logistic regression analysis were used to analyze the correlation between these clinical factors and successful ablation.Results In univariate analysis, six factors including age (≤48 years, OR 4.49, 95% CI 1.20-16.81, P = 0.03), LBM (>43.3 kg, OR 5.88, 95% CI 1.56-25.00, P = 0.01), sTg (≤1.69 ng/mL, OR 4.92, 95% CI 1.66-14.60, P = 0.004), BUN (≤11.8 mg/dL, OR 4.24, 95% CI 1.45-12.46, P = 0.01), ALP (≤261 IU/L, OR 8.25, 95% CI 2.54-26.85, P < 0.01) were significantly associated with successful ablation. In multivariate analysis, LBM (OR 0.05, 95% CI 0.01-0.38, P = 0.03), BUN (OR 6.01, 95% CI 1.36-26.62, P = 0.02) and ALP (OR 16.86, 95% CI 2.68-106.15, P < 0.01) showed significant association with successful ablation.Conclusions According to our result, LBM (>43.3 kg), BUN (≤11.8 mg/dL) and ALP (≤261 IU/L) were significantly correlated with successful ablation in rhTSH aided radioiodine therapy for differentiated thyroid cancer.