RT Journal Article
SR Electronic
T1 Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis on Preoperative 18F-fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography in Patients with Renal Cell Carcinoma
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1565
OP 1565
VO 57
IS supplement 2
A1 Reiko Nakajima
A1 Koichiro Abe
A1 Ken Kimura
A1 Tsunenori Kondo
A1 Shuji Sakaji
YR 2016
UL http://jnm.snmjournals.org/content/57/supplement_2/1565.abstract
AB 1565Objectives We evaluated the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured using pretreatment 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in patients with renal cell carcinoma (RCC).Methods A total of 119 patients with 125 RCCs who had undergone FDG-PET/CT before tumor resection were retrospectively reviewed. We determined maximum standardized uptake value (SUVmax), MTV, and TLG and compared the results obtained with those required for a progression-free survival (PFS), which was defined as the absence of local recurrence and progression metastases. Receiver operating characteristic curve analysis was used to compare prediction accuracies. Univariate and multivariate analyses of conventional clinicopathological variables [age, sex, pathological tumor node metastasis (pTNM) stage, histological type, Fuhrman grade, and presence/absence of microscopic lymphatic (Ly) and venous (V) invasions] were used to compare the reliability of the metabolic parameters (SUVmax, MTV, and TLG).Results Of the 119 patients with 125 tumors, 25 (21%) patients experienced recurrence or diseases progression during the follow-up period. The median PFS time was 11.7 months. From the ROC curve analyses, the age cutoff value was 61, with a sensitivity of 84% and a specificity of 43%; SUVmax cutoff value was 3.83, with a sensitivity of 92% and a specificity of 75%; the MTV cutoff value was 10.38 cm3, with a sensitivity of 96% and a specificity of 72%; and the TLG cutoff value was 20.8 , with a sensitivity of 100% and a specificity of 70%. The age, pTNM stage, Fuhrman grade, presence/absence of microscopic Ly and, V invasions, SUVmax, MTV, and TLG were significant prognostic factors for PFS (p< 0.05) on univariate analyses. Multivariate analyses revealed that TLG (p=0.02; hazard ratio, 9.5; 95% confidence interval, 1.4- 191) was the only independent predictor of PFS (table).Conclusions The pretreatment value of TLG is the only independent prognostic factor in patients with RCC. View this table:Multivariate Analyses of Clinicopathological and Imaging Variables on PFS