TY - JOUR T1 - SUVmax of the FDG-avid metastatic lesions before I-131 therapy for differentiated thyroid carcinoma is a powerful independent prognostic factor JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1448 LP - 1448 VL - 57 IS - supplement 2 AU - Yuko Uchiyama AU - SHOZO OKAMOTO AU - Tohru Shiga AU - Florian Gaertner AU - Kenji Hirata AU - Osamu Manabe AU - Kentaro Kobayashi AU - Shiro Watanabe AU - TAKUYA TOYONAGA AU - Yoichi Ito AU - Keiichiro Yoshinaga AU - Nagara Tamaki Y1 - 2016/05/01 UR - http://jnm.snmjournals.org/content/57/supplement_2/1448.abstract N2 - 1448Objectives Fluorodeoxyglucose positron emission tomography (FDG-PET) is effective for the survey of metastatic lesions from differentiated thyroid cancer and the prediction of the effect of tumor ablation. Although the presence or absence of FDG uptake is considered to affect the prognosis, there have been no reports on the FDG uptake level in such lesions to the best of our knowledge. In this study, the relationship between the maximum standardized uptake value (SUVmax, a semi-quantitative value that indicates the FDG uptake level in metastatic lesions from differentiated thyroid cancer and the prognosis of patients with such metastatic lesions was examined.Methods Patients who were admitted to Hokkaido University Hospital for the treatment of the metastatic lesions from differentiated thyroid cancer and were administered I-131 orally (I-131 therapy) were enrolled in this retrospective study. Among 819 patients studied, 309 patients showing positive FDG uptake in metastatic lesions on PET before the first I-131 therapy were analyzed. The mean and maximum follow-up periods were 56.9 and 144.6 months, respectively. SUVmax of the metastatic lesions was determined by FDG-PET. The relationships among SUVmax, gender, age, metastatic sites, and prognosis were analyzed by univariate and multivariate analyses using the Kaplan-Meier method and a Cox regression model, respectively.Results The five-year and ten-year survival rates were 81.6% and 53.4%, respectively. The results of the analysis using the Kaplan-Meier method revealed that the prognosis of the patients who are male (p = 0.0364), 蠅45 years old (p = 0.0023), with SUVmax 蠅4.0 (p <0.0001), or with distant metastasis (p <0.0001) was statistically significantly poor. The results of multivariate analysis revealed that SUVmax (p = 0.0011), age (p <0.0001), and metastatic sites (p = 0.0002) were independent prognostic factors.Conclusions In conclusion, SUVmax is a powerful independent prognostic factor for patients with FDG-avid metastatic lesions from differentiated thyroid carcinoma. ER -