TY - JOUR T1 - Ga-68-PSMA11 PET/CT vs. multi-parametric MRI for primary prostate cancer T-staging JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1542 LP - 1542 VL - 57 IS - supplement 2 AU - Frederik Giesel AU - Florian Sterzing AU - Maria Rius-Montraveta AU - Heinz Schlemmer AU - Uwe Haberkorn AU - Clemens Kratochwil Y1 - 2016/05/01 UR - http://jnm.snmjournals.org/content/57/supplement_2/1542.abstract N2 - 1542Objectives Multi-parametric magnetic resonance imaging (MP-MRI) is considered the standard of reference for imaging based primary tumor staging in prostate cancer (PCa). PSMA-PET/CT is on the way to become state-of-the-art for N- and M-staging in recurrent PCa-patients. Objective of this investigation is to analyses the T-staging potential of 68Ga-PSMA11-PET/CT in intra-individual comparison to MP-MRI.Methods In a retrospective study, 10 patients with primary PCa underwent MP-MRI and PSMA-PET/CT for initial staging. All tumors were proven histopathological by biopsy. Image analysis was done in a quantitative (SUVmax-Values) and qualitative (blinded read) fashion based on PI-RADS. The PI-RADS schema was then translated into a 3D-matrix and the Euclidian distance of this coordinate system was used to quantify the extend of agreement.Results Both MP-MRI and PSMA-PET/CT presented a good allocation of the PCa, which was also in concordance to the tumor location validated in 8-segment resolution by biopsy. An Isocour of 50% SUVmax in PSMA-PET resulted in visually concordant tumor extension in comparison to MP-MRI (T2w and DWI). For 89.4% of sections containing a tumor according to MP-MRI the tumor was also identified in total or sub-total agreement (Euclidian distance ≤1) by PSMA-PET. Vice versa for 96.8% of the sections identified as tumor bearing by PSMA-PET the tumor was also found in total or sub-total agreement by MP-MRI.Conclusions PSMA-PET/CT and MP-MRI correlated well in regard to tumor allocation in patients with a high pre-test probability for large tumors. Further research will be needed to evaluate its value in challenging situation such as small tumors, prostatitis or after repeated negative biopsies. ER -